代谢组学技术在骨关节炎不同研究对象中的应用
Application of Metabolomics Techniques in Different Subjects of Osteoarthritis2Yunnan Branch, Institute of Medicinal Plant Research, Chinese Academy of Medical Sciences & Peking Union Medical College Pharmacology Center, Jinghong Yunnan
DOI: 10.12677/acm.2025.15102810, PDF,    科研立项经费支持
作者: 陈江龙, 夏 彬, 周汝婕：黑龙江中医药大学药学院，黑龙江 哈尔滨；崔芸菲：中国医学科学院北京协和医学院药用植物研究所云南分所药理中心，云南 景洪；苏锦华：西双版纳傣族自治州药品监督检验研究院，云南 景洪；王金辉：西双版纳傣药研究院有限公司，云南 景洪；李 光*：中国医学科学院北京协和医学院药用植物研究所云南分所药理中心，云南 景洪；云南省南药可持续利用研究重点实验室，云南 景洪
关键词: 生物标志物；代谢途径；代谢组学；骨关节炎；Biomarkers； Metabolic Pathways； Metabolomics； Osteoarthritis
摘要: 骨关节炎(OA)是全球最普遍和最致残的关节炎，因为它具有异质性和进行性关节退化。然而这种疾病缺乏有效和及时的诊断和基础治疗。代谢组学是近年来生命科学研究中一个不断发展的领域，因为其具有检测许多代谢物的潜力，从而解释潜在的病理生理过程，因此可以确定OA的新特异性代谢标志物和相关代谢途径。在本综述中，我们旨在概述动物模型中OA代谢组学相关的研究，以描述OA的代谢变化和相关途径。
Abstract: Osteoarthritis (OA) is the most prevalent and disabling form of arthritis globally, characterized by its heterogeneity and progressive joint degeneration. However, effective and timely diagnostic methods and fundamental treatments for this disease remain lacking. Metabolomics represents an evolving field in life science research in recent years, as it holds the potential to detect numerous metabolites, thereby elucidating underlying pathophysiological processes. Consequently, it can identify novel specific metabolic biomarkers and associated metabolic pathways for OA. In this review, we aim to summarize studies related to OA metabolomics in animal models, in order to depict the metabolic alterations and relevant pathways in OA.
文章引用：陈江龙, 夏彬, 周汝婕, 崔芸菲, 苏锦华, 王金辉, 李光. 代谢组学技术在骨关节炎不同研究对象中的应用[J]. 临床医学进展, 2025, 15(10): 712-718. https://doi.org/10.12677/acm.2025.15102810

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