GFAP抗体重叠综合征的研究进展
Research Progress on GFAP Antibody Overlap Syndromes
DOI: 10.12677/acm.2025.15102824, PDF,   
作者: 彭芹芹：重庆医科大学附属儿童医院神经内科，重庆；重庆市万盛经济技术开发区人民医院儿科，重庆；吴 鹏*：重庆医科大学附属儿童医院神经内科，重庆
关键词: GFAP-IgG；重叠抗体；重叠综合征；GFAP-IgG； Overlapping Antibody； Overlap Syndrome
摘要: 自身免疫性胶质纤维酸性蛋白星形胶质细胞病(autoimmune glial fibrillary acidic protein astrocytopathy, GFAP-A)是一种新型的类固醇反应性中枢神经系统自身免疫炎性疾病，抗GFAP抗体是该病特异的生物学标志物。近年来，随着抗神经抗体谱系的不断扩展与普遍应用，GFAP-IgG阳性病例与日俱增，据报道该病约30%~40%合并其他抗体，临床共存疾病的病例报道日渐增多，一些病例队列研究或临床观察性研究也证实临床存在重叠综合征现象，现就近年来报道的GFAP抗体重叠现象或者重叠综合征的研究进行回顾，探讨重叠综合征的机制及临床意义。
Abstract: Autoimmune glial fibrillary acidic protein astrocytopathy (GFAP-A) is a novel steroid-responsive autoimmune inflammatory disorder of the central nervous system, with anti-GFAP antibodies serving as a specific biological marker for the disease. In recent years, with the expanding and widespread application of neural antibody testing, the number of GFAP-IgG positive cases has been increasing. It has been reported that approximately 30%~40% of these cases are associated with other antibodies, and there has been a growing number of clinical reports describing coexisting diseases. Several case series and clinical observational studies have confirmed the presence of overlap syndromes in clinical practice. This article reviews recent research on GFAP antibody overlap phenomena or overlap syndromes, and discusses the mechanisms and clinical significance of these overlap syndromes.
文章引用：彭芹芹, 吴鹏. GFAP抗体重叠综合征的研究进展[J]. 临床医学进展, 2025, 15(10): 822-832. https://doi.org/10.12677/acm.2025.15102824

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