椎间盘退变的生物治疗研究进展
Advances in the Biological Therapies of Intervertebral Disc Degeneration
摘要: 文章系统综述椎间盘退变(Intervertebral Disc Degeneration，以下简称IDD)的生物治疗研究进展。IDD作为一种常见的退行性疾病，严重影响患者生活质量并带来社会经济负担。传统治疗方法虽可缓解症状，却难以逆转退变进程。近年来，生物治疗策略展现出显著潜力，包括小分子化合物治疗(抗炎、抗氧化、调控代谢等)、细胞疗法(如间充质干细胞移植)、基因治疗(靶向基因编辑与调控)和组织工程(生物活性支架与再生医学策略)等，为椎间盘再生修复提供了新方向。然而，这些新型治疗手段仍面临药物稳定性、干细胞存活与安全性、载体效率及材料生物相容性等多重挑战。未来研究应注重多学科交叉融合、中西医结合和个体化治疗，以推动IDD生物治疗技术的临床转化与应用。
Abstract: This systematic review summarizes the pathological mechanisms and advances in biological therapies for intervertebral disc degeneration (IDD). As a prevalent degenerative disorder, IDD severely compromises patients’ quality of life and imposes substantial socioeconomic burdens. Conventional treatments only palliate symptoms without reversing the degenerative cascade. Recently, biological strategies—including small-molecule agents (anti-inflammatory, antioxidant and metabolic modulators), cell-based therapies (e.g., mesenchymal stem-cell transplantation), gene therapy (targeted editing and regulation) and tissue engineering (bioactive scaffolds and regenerative strategies)—have shown remarkable promise for disc regeneration, providing a new direction for intervertebral disc regeneration and repair. Nevertheless, clinical translation is still hindered by challenges such as drug stability, stem-cell survival and safety, vector efficiency and biomaterial biocompatibility. Future research should emphasize interdisciplinary integration, the synergy of traditional Chinese and Western medicine, and individualized therapy to accelerate the clinical application of IDD biological interventions.
文章引用：林可心, 李若烟, 樊效鸿. 椎间盘退变的生物治疗研究进展[J]. 临床医学进展, 2025, 15(10): 1000-1009. https://doi.org/10.12677/acm.2025.15102848

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