m6A修饰调控lncRNA在女性生殖系统肿瘤中的研究进展
Research Progress on m6A Modification Regulation of lncRNA in Female Reproductive System Tumors
DOI: 10.12677/acm.2025.15102889, PDF,    科研立项经费支持
作者: 池淑琦：山东大学齐鲁医院妇产科，山东 济南
关键词: m6A修饰；lncRNA；妇科肿瘤；表观遗传调控；甲基化；N6-Methyladenosine (m6A)； lncRNA； Gynecologic Oncology； Epigenetic Regulation； Methylation
摘要: 女性生殖系统肿瘤是严重威胁女性健康的主要疾病之一，其发生发展涉及复杂的表观遗传调控机制。近年来，N6-甲基腺苷(m6A)修饰和长链非编码RNA (lncRNA)在肿瘤中的作用日益受到关注。m6A作为真核生物mRNA中最常见的RNA甲基化修饰，可通过调控RNA的稳定性、剪接、翻译等过程影响基因表达。而lncRNA则作为重要的调控分子，参与肿瘤发生、转移和耐药等过程。越来越多的研究表明，m6A修饰可通过调控lncRNA的表达和功能影响妇科肿瘤的发生发展。本文综述了m6A修饰对lncRNA的调控机制，并探讨其在卵巢癌、宫颈癌和子宫内膜癌等妇科肿瘤中的研究进展，同时展望m6A-lncRNA轴在肿瘤诊断和治疗中的潜在应用价值。
Abstract: Tumors of the female reproductive system are one of the major diseases that seriously threaten women’s health, and their occurrence and development involve complex epigenetic regulatory mechanisms. In recent years, the role of N6 methyladenosine (m6A) modification and long non-coding RNA (lncRNA) in tumors has received increasing attention. As the most common RNA methylation modification in eukaryotic mRNA, m6A can affect gene expression by regulating RNA stability, splicing, translation, and other processes. As an important regulatory molecule, lncRNA is involved in processes such as tumorigenesis, metastasis, and drug resistance. More and more studies have shown that m6A modification can affect the occurrence and development of gynecological tumors by regulating the expression and function of lncRNA. This article reviews the regulatory mechanism of m6A modification on lncRNA and explores its research progress in gynecological tumors such as ovarian cancer, cervical cancer, and endometrial cancer. It also looks forward to the potential application value of m6A lncRNA axis in tumor diagnosis and treatment.
文章引用：池淑琦. m6A修饰调控lncRNA在女性生殖系统肿瘤中的研究进展[J]. 临床医学进展, 2025, 15(10): 1327-1333. https://doi.org/10.12677/acm.2025.15102889

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