高甘油三酯血症性急性胰腺炎的发病机制及诊疗进展
Hypertriglyceridemia-Associated Pancreatitis: Pathogenesis and Advances in Diagnosis and Treatment
DOI: 10.12677/acm.2025.15102918, PDF,    科研立项经费支持
作者: 钱 灯*, 叶添华：吉首大学医学院，湖南 吉首；赵志坚, 谭文亮, 朱泽民, 陈 迅#：中南大学湘雅医学院附属株洲医院肝胆胰脾外科，湖南 株洲
关键词: 高甘油三酯血症；急性胰腺炎；发病机制；治疗；Hypertriglyceridemia； Acute Pancreatitis； Pathogenesis； Therapy
摘要: 急性胰腺炎(Acute pancreatitis, AP)是临床常见的急腹症，由于不同的因素引起胰腺本身的消化酶激活，造成胰腺细胞的破坏，进而引起一系列如水肿、坏死等相关局部炎症反应，表现为腹膜炎症状和血清胰酶升高的胰腺急性炎症过程，高甘油三酯血症性急性胰腺炎(Hypertriglyceridemia-associated pancreatitis, HTG-AP)与其他类型胰腺炎存在明显差别，往往会引起较为严重的机体损害，病情迅速恶化，并发症较多，且病死率较高。本文综述了高甘油三酯血症性急性胰腺炎的发病机制及诊疗进展，旨在提高临床上对该疾病的认知和重视。
Abstract: Acute pancreatitis is a common clinical acute abdomen, characterized by peritoneal inflammation symptoms and elevated serum pancreatic enzymes, representing an acute inflammatory process of the pancreas. It was previously believed that the most common etiologies of acute pancreatitis are biliary and alcoholic. However, with changes in dietary structure, the incidence of hypertriglyceridemia-associated pancreatitis (HTG-AP) has gradually increased, and it has become the second most common cause of acute pancreatitis in China. HTG-AP is significantly different from other types of pancreatitis, often causing more severe damage to the body, with rapid deterioration of the condition, more complications, and a higher mortality rate. This article reviews the pathogenesis, diagnosis, and treatment progress of hypertriglyceridemia-associated pancreatitis, aiming to improve clinical awareness and attention to this disease.
文章引用：钱灯, 赵志坚, 谭文亮, 朱泽民, 叶添华, 陈迅. 高甘油三酯血症性急性胰腺炎的发病机制及诊疗进展[J]. 临床医学进展, 2025, 15(10): 1540-1548. https://doi.org/10.12677/acm.2025.15102918

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