齐墩果酸抗肿瘤作用机制的研究进展
Research Progress on the Anti-Tumor Mechanism of Oleanolic Acid
DOI: 10.12677/acm.2025.15102920, PDF,   
作者: 曲红彩, 李若南, 赵 政, 王珺屹, 周继来, 包秀文：黑龙江中医药大学研究生院，黑龙江 哈尔滨；姜家康*：黑龙江中医药大学附属第一医院肿瘤科，黑龙江 哈尔滨
关键词: 齐墩果酸；抗肿瘤；作用机制；Oleanolic Acid； Antitumor； Mechanism of Action
摘要: 齐墩果酸(OA)是一种普遍存在于植物界的五环三萜类化合物。由于其在多种疾病中的生物活性，科学界对其表现出广泛的关注。齐墩果酸能够通过多种途径发挥抗肿瘤作用。文章旨在综合阐述齐墩果酸在抑制肿瘤细胞增殖、诱导细胞凋亡、抑制肿瘤细胞的侵袭和转移、抑制肿瘤血管新生、调控基因表达、化学增敏以及逆转多药耐药等方面的抗肿瘤机制。通过对齐墩果酸抗肿瘤作用的全面了解，为今后临床研发治疗肿瘤的药物提供科学依据。
Abstract: Oleanolic acid (OA) is a pentacyclic triterpenoid compound abundant in the plant kingdom. Due to its diverse biological activities, it has attracted considerable attention from the scientific community. OA exhibits potent anti-tumor effects through various molecular pathways. This review aims to comprehensively elucidate the mechanisms underlying its anti-tumor activity, including inhibition of tumor cell proliferation, induction of tumor cell apoptosis, suppression of tumor cell invasion and metastasis, inhibition of tumor angiogenesis, regulation of gene expression, chemical sensitization, and reversal of multidrug resistance. A comprehensive understanding of these mechanisms provides a scientific basis for the future development of OA as a potential anti-tumor drug.
文章引用：曲红彩, 李若南, 赵政, 王珺屹, 周继来, 包秀文, 姜家康. 齐墩果酸抗肿瘤作用机制的研究进展[J]. 临床医学进展, 2025, 15(10): 1557-1564. https://doi.org/10.12677/acm.2025.15102920

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