HPV疫苗与宫颈癌研究的二十年演进与热点迁移:一项知识图谱分析
Twenty-Year Evolution and Shift of Research Focus in HPV Vaccine and Cervical Cancer Studies: A Knowledge Mapping Analysis
摘要: 背景:宫颈癌是女性第四大常见恶性肿瘤,疫苗的产生正极大地改变宫颈癌的防治格局。本研究旨在评估21世纪以来该领域的全球研究趋势,通过文献计量学,将研究现状与研究焦点进行可视化分析,从而全面概述人乳头瘤病毒(human papilloma virus, HPV)疫苗接种对宫颈癌的影响。方法:本研究检索了Web of Science (WOS)数据库中2000年至2022年间发表的关于HPV疫苗接种的研究文献。利用R语言的“Bibliometric”软件包、CiteNetExplorer、VOSviewer及CiteSpace软件,对区域、机构、期刊、作者和关键词等进行分析,以描绘最新研究趋势并预测下一个热点话题。结果:2000年至2022年间,共有6899篇文章被纳入本次研究,作者、机构、国家间均有相互合作,随着时间的进展,研究焦点转向对疫苗接种效果的监测与评估。结论:本研究全面描绘了过去20年间HPV疫苗接种研究领域的知识结构与发展方向,为优化疫苗分配策略、克服接种障碍及制定差异化宫颈癌防控方案提供了科学依据。
Abstract: Background: Cervical cancer is the fourth most common malignant tumor in women, and the development of vaccines has profoundly transformed the landscape of its prevention and treatment. This study aims to evaluate global research trends in this field since the 21st century through bibliometric methods, visually analyzing the current research status and focal points to provide a comprehensive overview of the impact of human papillomavirus (HPV) vaccination on cervical cancer. Methods: We retrieved research articles on HPV vaccination published between 2000 and 2022 from the Web of Science (WOS) database. Using R’s “Bibliometric” package, CiteNetExplorer, VOSviewer, and CiteSpace, we analyzed regions, institutions, journals, authors, and keywords to delineate the latest research trends and predict emerging hot topics. Results: A total of 6899 articles were included in this study. Collaborative networks were observed among authors, institutions, and countries. Over time, the research focus has shifted toward monitoring and evaluating the effectiveness of vaccination. Conclusion: This study comprehensively outlines the knowledge structure and development trajectory of HPV vaccination research over the past two decades, providing a scientific basis for optimizing vaccine allocation strategies, overcoming vaccination barriers, and formulating differentiated cervical cancer prevention and control plans.
文章引用:王欣仪, 王亚芬, 陈邦捷, 胡昕阳, 王凡. HPV疫苗与宫颈癌研究的二十年演进与热点迁移:一项知识图谱分析 [J]. 临床医学进展, 2025, 15(10): 1596-1608. https://doi.org/10.12677/acm.2025.15102924

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