疑似钛过敏致早期种植失败伴周围组织坏死一例
Early Implant Failure with Peri-Implant Tissue Necrosis Suspected Due to Titanium Allergy: A Case Report
DOI: 10.12677/acm.2025.15102928, PDF,   
作者: 李诗琪, 刘雁鸣*：浙江大学医学院附属第二医院口腔颌面外科，浙江 杭州
关键词: 种植体；钛过敏；种植失败；种植体周组织坏死；Implant； Titanium Allergy； Implant Failure； Peri-Implant Tissue Necrosis
摘要: 钛种植体因其良好的生物相容性被广泛应用于牙列缺损修复，但极少数患者可能发生钛过敏反应，导致种植体周围组织异常甚至早期失败。本文报道一例患者种植术后出现多颗种植体周围组织坏死、骨暴露及种植体松动的病例。尽管进行了抗感染和清创处理，症状仍未见好转，直至种植体取出后得以改善，该临床表现高度提示钛过敏。本文探讨了钛过敏的潜在机制、临床表现及处理策略，强调术前详细询问金属过敏史并对高风险患者进行过敏原检测的重要性，以预防此类罕见的并发症。
Abstract: Titanium is extensively utilized in dental implant therapy owing to their favorable biocompatibility. However, in rare instances, patients may develop allergy reactions, leading to peri-implant tissue abnormalities and early implant failure. This report presents a case in which multiple implants exhibited peri-implant tissue necrosis, bone exposure, and mobility shortly after placement. The symptoms failed to resolve with antibiotic therapy and debridement but improved only after the removal of the implant, strongly suggesting titanium allergy. The article discusses the potential mechanisms, clinical manifestations, and management strategies associated with titanium allergy. It underscores the critical importance of obtaining a detailed history of metal allergy and conducting preoperative hypersensitivity testing in high-risk patients to prevent such rare complications.
文章引用：李诗琪, 刘雁鸣. 疑似钛过敏致早期种植失败伴周围组织坏死一例[J]. 临床医学进展, 2025, 15(10): 1634-1641. https://doi.org/10.12677/acm.2025.15102928

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