基于中医“脾”探讨肠道菌群与骨质疏松症的相关性

Exploring the Correlation between Gut Microbiota and Osteoporosis Based on the Concept of the “Spleen” in Traditional Chinese Medicine

摘要: 骨质疏松症是一种全身性代谢性骨病，肠道菌群紊乱被证实为骨质疏松症的致病因素之一。中医“脾”脏与肠道菌群的功能非常相似，中医学理论认为肝脾肾亏虚、血瘀、痰浊均是骨质疏松的病因，其与肠道菌群紊乱导致骨质疏松症的很多机制极为类似，本文对三者之间的关系进行探讨，对“脾”与肠道菌群引起骨质疏松的病因病机进行了概述，以期充分挖掘中医学在骨质疏松症治疗领域的潜力。

Abstract: Osteoporosis is a systemic metabolic bone disease, and gut microbiota dysbiosis has been identified as one of its causative factors. The function of the spleen in Traditional Chinese Medicine (TCM) closely parallels that of the gut microbiota. Traditional Chinese medical theory posits that deficiencies in the liver, spleen, and kidney, blood stasis, and phlegm-dampness are all causative factors of osteoporosis. The mechanisms by which these conditions contribute to osteoporosis are highly analogous to those involving gut microbiota dysbiosis. This paper explores the relationships among these three factors, providing an overview of the pathogenesis of osteoporosis induced by the “spleen” and gut microbiota. The aim is to fully tap into the potential of Traditional Chinese Medicine in the treatment of osteoporosis.