基于H₂L-ZnTb的OTC-HCl传感器的合成与荧光传感性能

Synthesis and Fluorescence Sensing Performance of H₂L-ZnTb-Based Sensors toward OTC-HCl

摘要: 本文系统研究了稀土配合物H₂L-ZnTb溶液的发光性质及其对盐酸土霉素(OTC-HCl)的荧光传感性能。实验表明，H₂L-ZnTb在DMSO溶液中经355 nm激发产生Tb³⁺的特征发射峰，显示出优异的稀土发光特性和良好的相纯度。进一步的传感实验发现，H₂L-ZnTb对多种抗生素表现出特异性响应，仅OTC-HCl能显著猝灭其荧光。滴定实验结果表明，其对OTC-HCl的检测限(LOD)为14.63 nM。机理研究表明，OTC-HCl的紫外吸收与H₂L-ZnTb激发光谱的显著重叠导致内过滤效应(IFE)，从而引起荧光猝灭。作为最有前途的化学传感器之一，H₂L-ZnTb可以有效地应用于OTC-HCl的检测。

Abstract: This study systematically investigates the luminescent properties of the rare-earth complex H₂L-ZnTb solution and its fluorescence sensing performance toward oxytetracycline hydrochloride (OTC-HCl). Experiments demonstrate that H₂L-ZnTb exhibits characteristic Tb³⁺ emission peaks upon 355 nm excitation in DMSO solution, thus revealing excellent rare-earth luminescence characteristics and good phase purity. Further sensing experiments reveal that H₂L-ZnTb exhibits specific responses to multiple antibiotics, with only OTC-HCl significantly quenching its fluorescence. Titration results indicate a limit of detection (LOD) of 14.63 nM for OTC-HCl. Mechanistic studies indicate that the significant overlap between OTC-HCl’s UV absorption and H₂L-ZnTb excitation spectrum induces an inner filter effect (IFE), leading to fluorescence quenching. As one of the most promising chemical sensors, H₂L-ZnTb can be effectively applied to the detection of OTC-HCl.