FKBP10在头颈部鳞状细胞癌的表达及临床意义
Expression and Clinical Significance of FKBP10 in Head and Neck Squamous Cell Carcinoma
DOI: 10.12677/acm.2025.15102948, PDF,    科研立项经费支持
作者: 徐洛嘉, 陈海润, 王艺润, 杜文梁, 李雅冬*：重庆医科大学附属第一医院口腔颌面外科，重庆
关键词: FKBP10；头颈部鳞状细胞癌；细胞外基质；TGF-β；FKBP10； Head and Neck Squamous Cell Carcinoma； Extracellular Matrix； TGF-β
摘要: 目的：本研究以期探究FKBP10在头颈鳞癌中的表达水平和可能的作用机制，为头颈鳞癌的治疗提供可能的新靶点。方法：基于TCGA数据，R 4.3.2分析FKBP10在HNSCC中的表达；GEPIA2数据库进行生存分析；通过R分析FKBP10表达与免疫浸润之间的关系；基于LinkedOmics及MSigDB数据库进行基因富集分析；STRING数据库构建蛋白质互作网络。结果：FKBP10在HNSCC组织中显著高表达(p < 0.001)，绘制ROC曲线AUC值为0.857。FKBP10高表达组总生存期缩短(p < 0.05)。免疫细胞浸润分析提示，FKBP10表达与CD8+ T细胞、M1巨噬细胞呈负相关(p < 0.001)，与M0 (p < 0.001)、M2 (p < 0.05)巨噬细胞呈正相关。基因富集分析揭示了FKBP10参与细胞外基质相关过程，FKBP10高表达样本中显著富集的生物学通路包括TGF-β、WNT、BMP等信号通路。PPI网络提示FKBP10与COL1A1密切互作。结论：FKBP10可能在头颈鳞癌中作为促癌分子，通过与COL1A1相互作用激活TGF-β信号通路，在诱导TAM向M2表型极化的同时，与TAM协同驱动ECM重塑，从而促进HNSCC的发生发展。因此，FKBP10有望成为HNSCC的潜在生物学标志物及新的治疗靶点。
Abstract: Purpose: To investigate the expression pattern and underlying mechanism of FKBP10 in head and neck squamous cell carcinoma (HNSCC), aiming to identify a potential therapeutic target. Methods: Based on data collected from The Cancer Genome Atlas (TCGA), the expression level of FKBP10 in HNSCC was analyzed using R 4.3.2. Associations between FKBP10 expression and immune cell infiltration levels were quantified with CIBERSORT algorithms. Gene enrichment analysis was conducted using LinkedOmics and MSigDB databases, while FKBP10-associated protein-protein interaction (PPI) networks were analyzed via the STRING database. Results: FKBP10 was significantly overexpressed in HNSCC tissues versus normal tissues (p < 0.001), with an AUC of 0.857. Patients with high FKBP10 expression exhibited shortened overall survival (p < 0.05). FKBP10 expression showed a negative correlation with CD8⁺ T cells and M1 macrophages (p < 0.001), but a positive correlation with M0 (p < 0.001) and M2 (p < 0.05) macrophages. Gene enrichment analysis revealed FKBP10 involvement in extracellular matrix (ECM)-related processes, with TGF-β, WNT, and BMP pathways being significantly enriched. PPI analysis identified COL1A1 as a key interactor. Conclusion: FKBP10 may function as an oncogenic molecule in HNSCC. Through interaction with COL1A1, it activates TGF-β signaling, induces M2-polarization of tumor-associated macrophages (TAMs), and synergizes with TAMs to drive ECM remodeling, thereby promoting HNSCC progression. Consequently, FKBP10 may serve as a promising biomarker and therapeutic target.
文章引用：徐洛嘉, 陈海润, 王艺润, 杜文梁, 李雅冬. FKBP10在头颈部鳞状细胞癌的表达及临床意义[J]. 临床医学进展, 2025, 15(10): 1792-1802. https://doi.org/10.12677/acm.2025.15102948

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