间充质干细胞来源外泌体在卵巢保护中的作用与临床应用
The Role and Clinical Application of Mesenchymal Stem Cell-Derived Exosomes in Ovarian Protection
DOI: 10.12677/acm.2025.15102988, PDF,   
作者: 彭麗思, 农 夏, 陈芷若：暨南大学附属第一医院第一临床医学院，广东 广州；王玉霞*：暨南大学附属第一医院生殖医学中心，广东 广州
关键词: 间充质干细胞外泌体；卵巢保护；细胞凋亡；原发性卵巢功能不全；叙述性综述；Mesenchymal Stem Cell-Derived Exosomes； Ovarian Protection； Apoptosis； Primary Ovarian Insufficiency； Narrative Review
摘要: 卵巢功能障碍严重威胁女性生殖健康，传统治疗手段存在局限性。间充质干细胞来源外泌体(MSC-Exos)作为新型无细胞治疗工具，通过递送生物活性分子调控卵巢微环境。本叙述性综述系统总结MSC-Exos通过抗炎、免疫调节、抗氧化、再生修复及抑制凋亡改善原发性卵巢功能不全、多囊卵巢综合征及化疗性卵巢损伤中的作用，并探讨其临床转化面临的挑战与未来方向。
Abstract: Ovarian dysfunction poses serious threats to female reproductive health. Mesenchymal stem cell-derived exosomes (MSC-Exos), as novel cell-free therapeutic agents, regulate ovarian microenvironment through bioactive cargo delivery. This narrative review systematically elaborates the mechanisms of MSC-Exos in improving primary ovarian insufficiency, polycystic ovary syndrome and chemotherapy-induced ovarian damage via anti-inflammatory, immunomodulatory, antioxidant, regenerative repair, and apoptosis-inhibiting effects, and discusses the challenges and future directions for clinical translation.
文章引用：彭麗思, 农夏, 陈芷若, 王玉霞. 间充质干细胞来源外泌体在卵巢保护中的作用与临床应用[J]. 临床医学进展, 2025, 15(10): 2095-2102. https://doi.org/10.12677/acm.2025.15102988

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https://blog.sciencenet.cn/blog-280034-1493916.html, 2025-07-16.

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