儿童急性淋巴细胞白血病合并颅内静脉窦血栓3例报告并文献复习
Cerebral Venous Sinus Thrombosis in Pediatric Acute Lymphoblastic Leukemia: Report of 3 Cases and Literature Review
DOI: 10.12677/acm.2025.15103017, PDF,   
作者: 林洪萍, 孙 妍, 赵艳霞, 王玲珍, 杨 静*：青岛大学附属医院儿童血液肿瘤科，山东 青岛；邵晓军：青岛大学附属医院神经内科，山东 青岛
关键词: 颅内静脉窦血栓；急性淋巴细胞白血病；儿童；Cerebral Venous Sinus Thrombosis； Acute Lymphoblastic Leukemia； Pediatric
摘要: 目的：探讨儿童急性淋巴细胞白血病(ALL)并发颅内静脉窦血栓(CVST)的危险因素、诊断、治疗及预后。方法：回顾性分析青岛大学附属医院2022年9月至2024年12月3例儿童ALL合并CVST患儿的临床资料并对相关文献进行复习。结果：3例患儿均为中高危ALL，CVST均发生在化疗的诱导缓解期，CTV、MRV对CVST诊断具有很好的敏感性，应用低分子肝素及利伐沙班序贯抗凝治疗均预后良好。结论：ALL合并CVST患儿早期诊断并给予正确有效的抗凝治疗对改善预后至关重要。
Abstract: Purpose: To investigate the risk factors, diagnosis, treatment, and prognosis of cerebral venous sinus thrombosis (CVST) in children with acute lymphoblastic leukemia (ALL). Methods: A retrospective analysis was conducted on the clinical data of 3 children with ALL complicated by CVST at the Affiliated Hospital of Qingdao University between September 2022 and December 2024, along with a review of relevant literature. Results: All three children were classified as having intermediate- or high-risk ALL. CVST occurred during the induction remission phase of chemotherapy. Computed tomography venography (CTV) and magnetic resonance venography (MRV) showed high sensitivity in diagnosing CVST. All patients achieved a favorable prognosis following sequential anticoagulant therapy with low molecular weight heparin and rivaroxaban. Conclusion: Early diagnosis and appropriate effective anticoagulant therapy are crucial for improving the prognosis of children with ALL complicated by CVST.
文章引用：林洪萍, 邵晓军, 孙妍, 赵艳霞, 王玲珍, 杨静. 儿童急性淋巴细胞白血病合并颅内静脉窦血栓3例报告并文献复习[J]. 临床医学进展, 2025, 15(10): 2333-2338. https://doi.org/10.12677/acm.2025.15103017

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