术前雾化吸入布地奈德对降低肺叶切除患者术后并发症的临床分析

Clinical Analysis of Preoperative Nebulized Inhalation of Budesonide in Reducing Postoperative Complications in Patients Undergoing Lobectomy

摘要: 目的：术前使用布地奈德雾化吸入对肺叶切除患者术后肺部并发症的疗效评估。方法：回顾性分析2024年1月至2024年12月在安徽医科大学第二附属医院胸外科术前行布地奈德雾化吸入和不进行任何雾化治疗的肺叶切除患者各60例，对这些患者的术后引流量、疼痛时间、拔管时间、出院时间、肺漏气发生率、肺功能损失情况进行评估，结果：布地奈德吸入组相比对照组术后引流量更少[(1032 ± 187.67) mL vs (774 ± 178.23) mL, P = 0.012]，术后疼痛持续时间短[(2.23 ± 0.78) d vs (1.78 ± 0.45) d, P = 0.023]，拔管时间短[(4.23 ± 1.67) d vs (3.43 ± 0.98) d, P = 0.036]，出院时间短[(5.76 ± 2.87) d vs (7.43 ± 1.89) d, P = 0.012]，漏气发生率低(18.33% vs 2.00%, P = 0.043)，肺功能恢复更快：FVC [(2.53 ± 0.71) L vs (3.03 ± 0.46) L, P = 0.009]；FEV1 [(1.98 ± 0.65) L vs (2.64 ± 0.39) L, P = 0.004]；FEV1/FVC [(78.22 ± 10.35) vs (87.13 ± 11.15), P = 0.031]；FEV1 (%) [(83 ± 11.23) vs (88 ± 12.39), P = 0.042]。结论：术前布地奈德雾化吸入可以改善肺叶切除患者术后并发症的出现，降低护理负担，值得临床推广。

Abstract: Objective: To evaluate the efficacy of preoperative budesonide nebulized inhalation on postoperative pulmonary complications in patients undergoing lobectomy. Method: A retrospective analysis was conducted on 60 patients who underwent lobectomy before budesonide nebulization inhalation and 60 patients who did not receive any nebulization therapy in the Department of Thoracic Surgery of the Second Affiliated Hospital of Anhui Medical University from January 2024 to December 2024. The postoperative drainage volume, pain duration, extubation time, incidence of pulmonary air leakage, and lung function loss of these patients were evaluated. Result: Compared with the control group, the budesonide inhalation group had less postoperative drainage volume [(1032 ± 187.67) mL vs (774 ± 178.23) mL, P = 0.012], and shorter postoperative pain duration [(2.23 ± 0.78) d vs (1.78 ± 0.45) d, P = 0.023].The extubation time was short [(4.23 ± 1.67) d vs (3.43 ± 0.98) d, P = 0.036], the discharge time was short [(5.76 ± 2.87) d vs (7.43 ± 1.89) d, P = 0.012], the incidence of air leakage was low (18.33% vs2.00%, P = 0.043), and the recovery of lung function was faster: FVC [(2.53 ± 0.71)L vs (3.03 ± 0.46)L, P = 0.009]; FEV1 [(1.98 ± 0.65) L vs (2.64 ± 0.39)L, P = 0.004]; FEV1 /FVC [(78.22 ± 10.35) vs (87.13 ± 11.15), P = 0.031]; FEV1 (%) [(83 ± 11.23) vs (88 ± 12.39), P = 0.042].Conclusion: Preoperative budesonide nebulized inhalation can improve the occurrence of postoperative complications in patients undergoing lobectomy, reduce the burden of nursing, and is worthy of clinical promotion.