RNA在酒精使用障碍及其相关疾病中的研究进展
Recent Advances in RNA Research in Alcohol Use Disorder and Related Diseases
DOI: 10.12677/acm.2025.15103037, PDF,   
作者: 诸葛夫豪, 刘传新*:济宁医学院精神卫生学院,山东 济宁
关键词: 酒精使用障碍mRNA非编码RNAAlcohol Use Disorder mRNA Non-Coding RNA
摘要: 酒精使用障碍(alcohol use disorder, AUD)是指多次使用酒精产品后产生的心理或躯体对酒精失去控制的病态性渴求,常伴有情绪改变及肝脏损伤等伴发疾病,对日常生活有显著的影响。目前酒精使用呈现年轻群体高消费趋势。近年来,随着生物学技术的日益发展,RNA研究成为研究AUD发病机制的热点。本文章从mRNA、非编码RNA两个方面对AUD的研究进展做一阐述。
Abstract: Alcohol use disorder (AUD) refers to a pathological craving for alcohol that results from repeated use of alcoholic beverages, often accompanied by mood changes and liver damage, and significantly impacting daily life. Currently, alcohol consumption is showing a trend toward higher consumption among younger populations. In recent years, with the rapid development of biological technologies, RNA research has become a hotspot in studying the pathogenesis of AUD. This article reviews the current progress in AUD research from two aspects: mRNA and non-coding RNA.
文章引用:诸葛夫豪, 刘传新. RNA在酒精使用障碍及其相关疾病中的研究进展[J]. 临床医学进展, 2025, 15(10): 2504-2510. https://doi.org/10.12677/acm.2025.15103037

参考文献

[1] World Health Organization (2024) Global Status Report on Alcohol and Health and Treatment of Substance Use Disorders.
[2] Wu, X., Fan, X., Miyata, T., Kim, A., Cajigas-Du Ross, C.K., Ray, S., et al. (2023) Recent Advances in Understanding of Pathogenesis of Alcohol-Associated Liver Disease. Annual Review of Pathology: Mechanisms of Disease, 18, 411-438. [Google Scholar] [CrossRef] [PubMed]
[3] 刘姝, 王炳元. 全球酒精相关性肝病的疾病负担正在不断增加[J]. 肝脏, 2025, 30(4): 420-424.
[4] Pacheco-Fiallos, B., Vorländer, M.K., Riabov-Bassat, D., Fin, L., O’Reilly, F.J., Ayala, F.I., et al. (2023) mRNA Recognition and Packaging by the Human Transcription-Export Complex. Nature, 616, 828-835. [Google Scholar] [CrossRef] [PubMed]
[5] Yang, W., Singla, R., Maheshwari, O., Fontaine, C.J. and Gil-Mohapel, J. (2022) Alcohol Use Disorder: Neurobiology and Therapeutics. Biomedicines, 10, Article No. 1192. [Google Scholar] [CrossRef] [PubMed]
[6] Besong, O.T.O., Koo, J.S. and Zhang, H. (2024) Brain lncRNA-mRNA Co-Expression Regulatory Networks and Alcohol Use Disorder. Genomics, 116, Article ID: 110928. [Google Scholar] [CrossRef] [PubMed]
[7] Pfefferbaum, A., Zahr, N.M., Sassoon, S.A., Kwon, D., Pohl, K.M. and Sullivan, E.V. (2018) Accelerated and Premature Aging Characterizing Regional Cortical Volume Loss in Human Immunodeficiency Virus Infection: Contributions from Alcohol, Substance Use, and Hepatitis C Coinfection. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 3, 844-859. [Google Scholar] [CrossRef] [PubMed]
[8] Sullivan, E.V., Zahr, N.M., Sassoon, S.A., Thompson, W.K., Kwon, D., Pohl, K.M., et al. (2018) The Role of Aging, Drug Dependence, and Hepatitis C Comorbidity in Alcoholism Cortical Compromise. JAMA Psychiatry, 75, 474-483. [Google Scholar] [CrossRef] [PubMed]
[9] Pihlajamäki, J., Lerin, C., Itkonen, P., Boes, T., Floss, T., Schroeder, J., et al. (2011) Expression of the Splicing Factor Gene SFRS10 Is Reduced in Human Obesity and Contributes to Enhanced Lipogenesis. Cell Metabolism, 14, 208-218. [Google Scholar] [CrossRef] [PubMed]
[10] Li, G., Chen, H., Shen, F., Smithson, S.B., Shealy, G.L., Ping, Q., et al. (2023) Targeting Hepatic Serine-Arginine Protein Kinase 2 Ameliorates Alcohol-Associated Liver Disease by Alternative Splicing Control of Lipogenesis. Hepatology, 78, 1506-1524. [Google Scholar] [CrossRef] [PubMed]
[11] Lu, Y., Xu, W., Ji, J., Feng, D., Sourbier, C., Yang, Y., et al. (2015) Alternative Splicing of the Cell Fate Determinant Numb in Hepatocellular Carcinoma. Hepatology, 62, 1122-1131. [Google Scholar] [CrossRef] [PubMed]
[12] Kimura, T. (2020) Non-coding Natural Antisense RNA: Mechanisms of Action in the Regulation of Target Gene Expression and Its Clinical Implications. Yakugaku Zasshi, 140, 687-700. [Google Scholar] [CrossRef] [PubMed]
[13] Iyer, M.K., Niknafs, Y.S., Malik, R., Singhal, U., Sahu, A., Hosono, Y., et al. (2015) The Landscape of Long Noncoding RNAs in the Human Transcriptome. Nature Genetics, 47, 199-208. [Google Scholar] [CrossRef] [PubMed]
[14] Kryger, R., Fan, L., Wilce, P.A. and Jaquet, V. (2012) MALAT-1, a Non Protein-Coding RNA Is Upregulated in the Cerebellum, Hippocampus and Brain Stem of Human Alcoholics. Alcohol, 46, 629-634. [Google Scholar] [CrossRef] [PubMed]
[15] 薛琳媛, 武南南, 封芮芮, 等. 双瓶选择饮酒致酒精依赖小鼠海马中长链非编码RNA的表达谱分析[J]. 中国生物制品学杂志, 2024, 37(5): 559-565.
[16] Zhu, S., Wu, J. and Hu, J. (2022) Non-coding RNA in Alcohol Use Disorder by Affecting Synaptic Plasticity. Experimental Brain Research, 240, 365-379. [Google Scholar] [CrossRef] [PubMed]
[17] Saba, L.M., Hoffman, P.L., Homanics, G.E., Mahaffey, S., Daulatabad, S.V., Janga, S.C., et al. (2020) A Long Non‐coding RNA (Lrap) Modulates Brain Gene Expression and Levels of Alcohol Consumption in Rats. Genes, Brain and Behavior, 20, e12698. [Google Scholar] [CrossRef] [PubMed]
[18] Yang, Z., Jiang, Y., Ma, J., Wang, L., Han, S., Huda, N., et al. (2024) LncRNA H19 Promoted Alcohol-Associated Liver Disease through Dysregulation of Alternative Splicing and Methionine Metabolism. Hepatology, 81, 1485-1500. [Google Scholar] [CrossRef] [PubMed]
[19] Du, Q., Xiao, R., Luo, R., Xie, J., Su, Z. and Wang, Y. (2022) Construction of Long Non-Coding RNA-and microRNA-Mediated Competing Endogenous RNA Networks in Alcohol-Related Esophageal Cancer. PLOS ONE, 17, e0269742. [Google Scholar] [CrossRef] [PubMed]
[20] Schnepper, A.P., Marques, L.F., Wolf, I.R., Kubo, A.M.S. and Valente, G.T. (2024) Potential Global Cis and Trans Regulation of lncRNAs in Saccharomyces Cerevisiae Subjected to Ethanol Stress. Gene, 920, Article ID: 148521. [Google Scholar] [CrossRef] [PubMed]
[21] Fu, G., Brkić, J., Hayder, H. and Peng, C. (2013) MicroRNAs in Human Placental Development and Pregnancy Complications. International Journal of Molecular Sciences, 14, 5519-5544. [Google Scholar] [CrossRef] [PubMed]
[22] Adlakha, Y.K. and Saini, N. (2014) Brain microRNAs and Insights into Biological Functions and Therapeutic Potential of Brain Enriched miRNA-128. Molecular Cancer, 13, Article No. 33. [Google Scholar] [CrossRef] [PubMed]
[23] Lim, Y., Beane-Ebel, J.E., Tanaka, Y., Ning, B., Husted, C.R., Henderson, D.C., et al. (2021) Exploration of Alcohol Use Disorder-Associated Brain miRNA-mRNA Regulatory Networks. Translational Psychiatry, 11, Article No. 504. [Google Scholar] [CrossRef] [PubMed]
[24] Lewis, S.A., Doratt, B., Sureshchandra, S., Pan, T., Gonzales, S.W., Shen, W., et al. (2021) Profiling of Extracellular Vesicle‐Bound miRNA to Identify Candidate Biomarkers of Chronic Alcohol Drinking in Nonhuman Primates. Alcoholism: Clinical and Experimental Research, 46, 221-231. [Google Scholar] [CrossRef] [PubMed]
[25] Cai, C., Lin, J., Li, J., Wang, X., Xu, L., Chen, D., et al. (2022) miRNA‐432 and SLC38A1 as Predictors of Hepatocellular Carcinoma Complicated with Alcoholic Steatohepatitis. Oxidative Medicine and Cellular Longevity, 2022, Article ID: 4832611. [Google Scholar] [CrossRef] [PubMed]
[26] Gangisetty, O., Chaudhary, S., Tarale, P., Cabrera, M.A. and Sarkar, D.K. (2023) miRNA-383 and miRNA-384 Suppress Proopiomelanocortin Gene Expression in the Hypothalamus: Effects of Early Life Ethanol Exposure. Neuroendocrinology, 113, 844-858. [Google Scholar] [CrossRef] [PubMed]
[27] Du, A., Chen, Y., Qiao, S., Dong, J., Li, Y., Cao, B., et al. (2024) Analysis of microRNAs and the microRNA-messengerRNA Regulatory Network in Chronic Alcohol Exposure. Frontiers in Pharmacology, 15, Article ID: 1377501. [Google Scholar] [CrossRef] [PubMed]
[28] Braicu, C., Zimta, A., Gulei, D., Olariu, A. and Berindan-Neagoe, I. (2019) Comprehensive Analysis of Circular RNAs in Pathological States: Biogenesis, Cellular Regulation, and Therapeutic Relevance. Cellular and Molecular Life Sciences, 76, 1559-1577. [Google Scholar] [CrossRef] [PubMed]
[29] Memczak, S., Jens, M., Elefsinioti, A., Torti, F., Krueger, J., Rybak, A., et al. (2013) Circular RNAs Are a Large Class of Animal RNAs with Regulatory Potency. Nature, 495, 333-338. [Google Scholar] [CrossRef] [PubMed]
[30] Liu, Y., Li, J., Bu, H., Wang, H., Zhang, Y., Shen, Q., et al. (2021) Circular RNA Expression Alteration Identifies a Novel Circulating Biomarker in Serum Exosomal for Detection of Alcohol Dependence. Addiction Biology, 26, e13031. [Google Scholar] [CrossRef] [PubMed]
[31] Daws, S.E. and Gillespie, A. (2023) Circular RNA Regulation and Function in Drug Seeking Phenotypes. Molecular and Cellular Neuroscience, 125, Article ID: 103841. [Google Scholar] [CrossRef] [PubMed]
[32] Papageorgiou, G., Amoah, S.K., Pierotti, C., Otero, M., Eckel, S., Coffey, K., et al. (2023) Prenatal Alcohol Exposure Results in Brain Region-and Sex-Specific Changes in circHomer1 Expression in Adult Mouse Brain. Frontiers in Neuroscience, 17, Article ID: 1087950. [Google Scholar] [CrossRef] [PubMed]
[33] Noor, S., Pritha, A.N., Pasmay, A.A., Sanchez, J.E., Sanchez, J.J., Fernandez-Oropeza, A.K., et al. (2023) Prenatal Alcohol Exposure Dysregulates Spinal and Circulating Immune Cell Circular RNA Expression in Adult Female Rats with Chronic Sciatic Neuropathy. Frontiers in Neuroscience, 17, Article ID: 1180308. [Google Scholar] [CrossRef] [PubMed]