[3 + 3]环加成反应研究进展
Research Progress on [3 + 3] Cycloaddition Reactions
DOI: 10.12677/amc.2025.134049, PDF,    国家自然科学基金支持
作者: 薛梓超, 陈家乐, 陈兴楠, 陈效威*, 樊晓辉*：兰州交通大学化学化工学院，甘肃 兰州
关键词: [3 + 3]环加成反应；六元环；芳香化合物；[3 + 3] Cycloaddition Reaction； Six-Membered Ring； Aromatic Compound
摘要: [3 + 3]环加成反应是有机合成中构建六元环的重要策略，其核心是两个含3原子反应片段(三原子砌块)的成环反应直接构建六元环。这种反应模式因高效、原子经济性好且能快速构建复杂分子骨架等优势被广泛应用于天然产物合成、药物化学及材料化学等领域。本文对近十年的[3 + 3]环加成反应进行了归纳总结，为该领域的研究者提供参考和借鉴。
Abstract: The [3 + 3] cycloaddition reaction is an important strategy in organic synthesis for the direct construction of six-membered ring through the cyclization of two 3-atom reaction fragments (three-atom building blocks). Owing to its advantages such as high efficiency, good atom economy, and the ability to rapidly construct complex molecular skeletons, this reaction mode is widely applied in natural product synthesis, medicinal chemistry and materials science. This paper summarizes and reviews the [3 + 3] cycloaddition reactions in the past decade, aiming to provide a reference for researchers in this field.
文章引用：薛梓超, 陈家乐, 陈兴楠, 陈效威, 樊晓辉. [3 + 3]环加成反应研究进展[J]. 材料化学前沿, 2025, 13(4): 481-492. https://doi.org/10.12677/amc.2025.134049

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