滤泡样生长方式的套细胞淋巴瘤2例并文献复习

Mantle Cell Lymphoma with Follicular Growth Pattern: Two Cases Report and Review Literature

摘要: 套细胞淋巴瘤是一种较为少见的B细胞淋巴瘤，兼具惰性和侵袭性非霍奇金淋巴瘤的特点。典型的套细胞淋巴瘤表现为单一的淋巴细胞增殖，根据组织结构可呈结节型、弥漫型、套区型或罕见的滤泡生长方式，其中以弥漫型最为常见，滤泡生长方式的套细胞淋巴瘤极为罕见。本文报道了具有滤泡生长方式的套细胞淋巴瘤2例，旨在探讨其病理特征及鉴别诊断要点，以提高对该特殊生长方式套细胞淋巴瘤的认识与诊断水平，避免漏诊或误诊。

Abstract: Mantle cell lymphoma (MCL) is a relatively rare subtype of B-cell non-Hodgkin lymphoma that shares clinicopathological features of both indolent and aggressive lymphomas. Histologically, classical MCL is characterized by a monomorphic proliferation of lymphocytes arranged in a variety of architectural patterns, including nodular, diffuse, mantle zone, and the exceptionally rare follicular growth pattern. Among these, the diffuse pattern is most frequently encountered, whereas the follicular variant is exceedingly uncommon. Herein, we report two cases of MCL exhibiting a follicular growth pattern. The purpose of this report is to elucidate the pathological characteristics and key diagnostic criteria for this morphological variant, with the aim of improving recognition, enhancing diagnostic accuracy, and reducing the potential for misdiagnosis or underdiagnosis.