强化谷氨酰胺的肠外营养治疗对结直肠癌患者术后营养状况、炎症指标及免疫功能的影响

The Effect of Glutamine-Enhanced Parenteral Nutrition on Postoperative Nutritional Status, Inflammatory Markers, and Immune Function in Colorectal Cancer Patients

摘要: 目的：探讨强化谷氨酰胺的肠外营养对于结直肠癌术后肠内营养不耐受患者营养状况、炎症指标和免疫功能的影响。方法：收集潍坊市人民医院结直肠外科2021年8月至2023年10月接受结直肠癌根治术患者的临床资料，统计分析两组患者术后营养指标、炎症因子和免疫功能的差异。结果：将113例结直肠癌手术患者根据肠外营养中是否添加谷氨酰胺分为干预组(强化谷氨酰胺，n = 59)和对照组(普通营养治疗，n = 54)。两组患者术后的血清白蛋白、白细胞计数、CRP、IL-6、IgA、IgG、IgM水平的变化趋势存在显著差异(P < 0.05)。结论：与普通营养治疗相比，术后补充谷氨酰胺的肠外营养可在改善患者营养指标的同时，降低炎症水平，提高免疫功能。

Abstract: Objective: To investigate the effects of parenteral nutrition supplemented with glutamine on nutritional status, inflammatory markers, and immune function in colorectal cancer patients with postoperative enteral nutrition intolerance. Methods: Clinical data of patients who underwent radical resection for colorectal cancer in the Colorectal Surgery Department of Weifang People’s Hospital between August 2021 and October 2023 were collected. The differences in postoperative nutritional indicators, inflammatory factors, and immune function between the two groups were statistically analyzed. Results: A total of 113 patients were divided into an intervention group (glutamine-supplemented nutrition, n = 59) and a control group (standard nutrition, n = 54) based on whether glutamine was added to the parenteral nutrition. The trends in changes of serum albumin, white blood cell count, CRP, IL-6, IgA, IgG, and IgM levels after surgery showed significant differences between the two groups (P < 0.05). Conclusion: Compared with standard nutrition therapy, postoperative parenteral nutrition supplemented with glutamine can improve nutritional indicators, reduce inflammation levels, and enhance immune function in patients.