丹皮酚对卵巢癌作用机制研究进展
Research Progress on the Mechanism of Paeonol in Ovarian Cancer
DOI: 10.12677/acm.2025.15113073, PDF,   
作者: 崔靖萱*：黑龙江中医药大学研究生院，黑龙江 哈尔滨；沈文娟#：黑龙江中医药大学附属第一医院妇科，黑龙江 哈尔滨
关键词: 丹皮酚；卵巢癌；综述；作用机制；Paeonol； Ovarian Cancer； Review； Mechanism
摘要: 卵巢癌是妇科常见的恶性肿瘤之一，早期诊断对卵巢癌的治疗非常重要。当前卵巢癌的治疗仍以手术化疗和靶向治疗为主，但此类疗法易引起多种不良反应，且应用范围有限，影响患者生活质量且极易复发。近年来，中药提取物治疗卵巢癌受到越来越多的关注和应用。丹皮酚是一种从牡丹皮中提取的苯丙素类化合物，具有抗氧化、抗肿瘤等药理作用。研究表明丹皮酚对卵巢癌的发生、发展的多个阶段具有显著治疗作用。其通过抑制OC细胞的增殖，抑制OC细胞侵袭、迁移，诱导OC细胞凋亡，调控肿瘤微环境，逆转多药耐药、抗肿瘤药物毒性作用等多种机制，延缓卵巢癌发生发展。总体而言，丹皮酚在卵巢癌疾病的治疗具有潜在应用价值，在一定范围内安全性高且副作用小，有望为临床药物开发提供重要参考。
Abstract: Ovarian cancer is one of the common malignant tumors in gynecology. Early diagnosis is of great significance for the treatment of ovarian cancer. Currently, the treatment of ovarian cancer still mainly relies on surgery, chemotherapy, and targeted therapy. However, these therapies are prone to causing various adverse reactions, have a limited application scope, affect patients’ quality of life, and lead to a high recurrence rate. In recent years, the use of traditional Chinese medicine extracts in the treatment of ovarian cancer has attracted increasing attention and application. Paeonol is a phenylpropanoid compound extracted from the root bark of Paeonia suffruticosa (peony bark). It possesses pharmacological effects such as antioxidation and antitumor activity. Studies have shown that paeonol exerts a significant therapeutic effect on multiple stages of the occurrence and development of ovarian cancer. It delays the occurrence and progression of ovarian cancer through multiple mechanisms, including inhibiting the proliferation, invasion, and migration of ovarian cancer (OC) cells, inducing the apoptosis of OC cells, regulating the tumor microenvironment, and reversing multidrug resistance. In general, paeonol has potential application value in the treatment of ovarian cancer. It has high safety and minimal side effects within a certain range, and is expected to provide important references for the development of clinical drugs.
文章引用：崔靖萱, 沈文娟. 丹皮酚对卵巢癌作用机制研究进展[J]. 临床医学进展, 2025, 15(11): 111-116. https://doi.org/10.12677/acm.2025.15113073

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