NLRP3炎性小体与2型糖尿病的关系及中医药调控研究进展
The Relationship between NLRP3 Inflammasome and Type 2 Diabetes Mellitus and the Research Progress of Traditional Chinese Medicine Regulation
DOI: 10.12677/pi.2025.146043, PDF,   
作者: 黄思源：黑龙江中医药大学研究生学院，黑龙江 哈尔滨；张 杨*：黑龙江中医药大学附属第一医院，黑龙江 哈尔滨
关键词: 2型糖尿病；NOD样受体热蛋白结构域3炎性小体；中医药；作用机制；Type 2 Diabetes Mellitus； NLRP3 Inflammasome； Chinese Medicine； Mechanism of Action
摘要: 目的：为今后中医药经NLRP3炎性小体治疗2型糖尿病的研究提供参考。方法：分析汇总近年来NLRP3炎性小体与2型糖尿病的研究文献，并就中医药经其干预2型糖尿病的作用机制来分类阐述。结果：在中医药经NLRP3炎性小体调控2型糖尿病的研究中，其主要作用机制为调节免疫反应，调控炎症信号通路，影响细胞焦亡、自噬等，减少炎性细胞因子的合成与释放。结论：中医药经NLRP3炎性小体治疗2型糖尿病的药理作用较为明确，但其作用机制和药用价值需要进一步研究。
Abstract: Objective: This study will provide a reference for the future research on the treatment of type 2 diabetes mellitus by NLRP3 inflammasome in traditional Chinese medicine. Methods: This paper analyzes and summarizes the research literature on NLRP3 inflammasome and type 2 diabetes mellitus in recent years, and classifies and expounds the mechanism of action of traditional Chinese medicine in the intervention of type 2 diabetes. Results: In the study of the regulation of type 2 diabetes by NLRP3 inflammasome in traditional Chinese medicine, the main mechanism of action is to regulate immune response, regulate inflammatory signaling pathways, affect pyroptosis, autophagy, etc., and reduce the synthesis and release of inflammatory cytokines. Conclusion: The pharmacological effects of traditional Chinese medicine in the treatment of type 2 diabetes mellitus through NLRP3 inflammasome are relatively clear, but its mechanism of action and medicinal value need to be further studied.
文章引用：黄思源, 张杨. NLRP3炎性小体与2型糖尿病的关系及中医药调控研究进展[J]. 药物资讯, 2025, 14(6): 379-387. https://doi.org/10.12677/pi.2025.146043

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