肥胖与感染：临床现状与研究进展
Obesity and Infection: Clinical Status and Research Progress
DOI: 10.12677/acm.2025.15113095, PDF,    科研立项经费支持
作者: 唐雪银, 潘 宇, 罗冬立, 蒋 洋：重庆医科大学附属第二医院老年医学科，重庆；袁 艳：中国人民解放军陆军军医大学第一附属医院呼吸与危重症科，重庆；董江川*：重庆医科大学附属第二医院老年医学科，重庆；重庆大学附属肿瘤医院中医肿瘤治疗中心，重庆
关键词: 肥胖；感染；免疫；代谢；Obesity； Infection； Immunity； Metabolism
摘要: 近年来，肥胖已成为全球重大公共卫生挑战。肥胖以持续慢性炎症状态和代谢紊乱为特点，已被证实是糖尿病、高血压、冠心病等多种慢性疾病的重要危险因素。同时，肥胖也被视为多种感染的独立危险因素，其不仅增加了机体对病原体的易感性，也会促进感染向重症化进展。其潜在机制涉及免疫功能失调、炎症反应失衡、代谢紊乱、肠道菌群结构改变等多重因素。本研究旨在探讨肥胖与感染之间的关联，有助于更好地理解其病理机制，为指导临床治疗提供理论依据。
Abstract: Obesity has become a major global public health challenge in recent years. Obesity is characterised by a persistent chronic inflammatory state and metabolic disorder, which has been confirmed to be an important risk factor for a variety of chronic diseases such as diabetes, hypertension, and coronary heart disease. At the same time, obesity is also considered an independent risk factor for a variety of infections, which not only increases the susceptibility of the body to pathogens but also promotes the progression of infection to severe disease. The underlying mechanism involves multiple factors, including immune dysfunction, inflammatory imbalance, metabolic disorders, and alterations in the intestinal flora structure. This study aims to explore the association between obesity and infection, with the goal of better understanding its pathological mechanism and providing a theoretical basis for guiding clinical treatment.
文章引用：唐雪银, 潘宇, 罗冬立, 蒋洋, 袁艳, 董江川. 肥胖与感染：临床现状与研究进展[J]. 临床医学进展, 2025, 15(11): 276-285. https://doi.org/10.12677/acm.2025.15113095

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