下一代测序技术在关节假体周围感染诊断中的价值与争议
The Value and Controversy of Next-Generation Sequencing Technology in the Diagnosis of Periprosthetic Joint Infection
摘要: 假体周围感染(periprosthetic joint infection, PJI)是关节置换术后的灾难性并发症，也是当前骨科医生必须面对的重大挑战。对PJI的准确诊断是克服PJI问题的前提条件，但目前由于缺乏明确的诊断金标准，其诊断仍面临挑战。近年来，有关PJI的诊断方法涌现出大量的科学研究，特别是下一代测序技术(next-generation sequencing, NGS)，因其快速、无偏向性地获取病原基因组信息的能力，已成为提高PJI诊断水平的重要工具，并在临床中得到广泛应用。但随着诊疗成功率的提高，如何采用更加精准且经济的检测方式进行诊断依旧值得我们深思。
Abstract: Periprosthetic joint infection (PJI) is a devastating complication following joint arthroplasty and remains a major challenge that orthopedic surgeons must confront. Accurate diagnosis of PJI is a prerequisite for addressing this issue; however, the absence of a definitive gold standard continues to pose diagnostic challenges. In recent years, a substantial body of scientific research has emerged on diagnostic methods for PJI, particularly next-generation sequencing (NGS). Due to its ability to rapidly and unbiasedly capture pathogen genomic information, NGS has become an important tool for improving the diagnostic accuracy of PJI and is now widely used in clinical practice. Nevertheless, despite improvements in diagnostic and treatment success rates, the pursuit of more precise and cost-effective diagnostic approaches remains a critical consideration.
文章引用：康润兴, 黄伟. 下一代测序技术在关节假体周围感染诊断中的价值与争议[J]. 临床医学进展, 2025, 15(11): 302-307. https://doi.org/10.12677/acm.2025.15113098

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