预康复在合并慢性阻塞性肺疾病肺癌手术患者中的研究进展

Research Advances in Prehabilitation for Surgical Lung Cancer Patients with Comorbid Chronic Obstructive Pulmonary Disease

摘要: 慢性阻塞性肺疾病(COPD)患者合并肺癌时，因肺功能受损、慢性炎症和代谢异常，手术风险显著增加，影响患者的围手术期管理和预后。预康复作为一种围手术期功能优化策略，近年来在该领域得到广泛关注。本文系统综述了近年来预康复在合并COPD肺癌手术患者中的研究进展，重点分析了精准化预康复干预、多学科团队协作模式、新型数字化技术赋能、与新辅助治疗的联合应用及基于生物标志物的风险预测等前沿方向。通过整合个体化功能评估与针对性干预措施，结合新技术和跨专业协作，实现围手术期患者功能状态的优化和术后并发症的降低。本文旨在为临床实践提供科学依据，推动预康复策略的标准化和精准化，促进合并COPD肺癌患者手术安全性和生活质量的提升。

Abstract: Patients with concurrent chronic obstructive pulmonary disease (COPD) and lung cancer face significantly increased surgical risks due to impaired pulmonary function, chronic inflammation, and metabolic abnormalities, which adversely affect perioperative management and prognosis. Prehabilitation, as a strategy for optimizing perioperative functional capacity, has gained considerable attention in this field in recent years. This article systematically reviews recent advances in prehabilitation for surgical lung cancer patients with comorbid COPD, focusing on cutting-edge approaches such as precise prehabilitation interventions, multidisciplinary team collaboration models, empowerment through novel digital technologies, integration with neoadjuvant therapy, and biomarker-based risk prediction. By combining individualized functional assessment with targeted interventions, along with new technologies and cross-disciplinary collaboration, prehabilitation aims to optimize perioperative functional status and reduce postoperative complications. This review aims to provide a scientific basis for clinical practice, promote the standardization and precision of prehabilitation strategies, and ultimately enhance surgical safety and quality of life for lung cancer patients with COPD.