基于肠–脑轴探讨气机升降失常在多囊卵巢综合征中的作用
Exploring the Role of Abnormal Qi Movement in Polycystic Ovary Syndrome Based on the Gut-Brain Axis
DOI: 10.12677/acm.2025.15113141, PDF,   
作者: 高惠莹：黑龙江中医药大学第一临床医学院，黑龙江 哈尔滨；匡洪影*：黑龙江中医药大学附属第一医院妇科二科 黑龙江 哈尔滨
关键词: 多囊卵巢综合征；气机升降；肠–脑轴；肠道微生物群；内分泌失调；Polycystic Ovary Syndrome； Qi Movement； Gut-Brain Axis； Gut Microbiota； Endocrine Disorder
摘要: 多囊卵巢综合征(Polycystic Ovary Syndrome, PCOS)作为一种常见的内分泌疾病，病理机制复杂，严重威胁了女性生殖和代谢健康。近年来，肠道微生物群在PCOS发病机制中的重要作用被揭示，尤其在调节内分泌和代谢方面。肠–脑轴作为连接肠道与中枢神经系统的双向调控通路，成为探究PCOS发病机制的新兴研究方向。本文围绕气机升降失常这一中医理论，系统综述其与肠道菌群失衡、神经内分泌紊乱之间的相互作用机制，揭示了肠–脑轴在PCOS病理中的关键作用。通过整合现代医学与传统中医理论的研究成果，本文为PCOS的诊断和治疗提供了新的理论依据和潜在靶点，推动了该领域的跨学科发展。
Abstract: Polycystic ovary syndrome (PCOS) is a common endocrine disorder with a complex pathogenic mechanism, seriously threatening female reproductive and metabolic health. In recent years, the crucial role of the gut microbiota in the pathogenesis of PCOS has been revealed, especially in regulating endocrine and metabolic functions. The gut-brain axis, as a bidirectional regulatory pathway connecting the gut and the central nervous system, has emerged as a new research direction in exploring the pathogenesis of PCOS. This article systematically reviews the interaction mechanisms among the imbalance of qi movement, gut microbiota dysbiosis, and neuroendocrine disorders based on the theory of qi movement in traditional Chinese medicine, revealing the key role of the gut-brain axis in the pathology of PCOS. By integrating the research achievements of modern medicine and traditional Chinese medicine theories, this article provides a new theoretical basis and potential targets for the diagnosis and treatment of PCOS, promoting the interdisciplinary development in this field.
文章引用：高惠莹, 匡洪影. 基于肠–脑轴探讨气机升降失常在多囊卵巢综合征中的作用[J]. 临床医学进展, 2025, 15(11): 645-653. https://doi.org/10.12677/acm.2025.15113141

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