芳基到烯基的1,4-钯迁移反应研究
Study on the 1,4-Palladium Migration Reaction from Aryl to Alkenyl
DOI: 10.12677/hjcet.2025.156031, PDF,    科研立项经费支持
作者: 武雅茹, 陈家乐, 孙文婷, 刘兆传, 王崔天*, 樊晓辉*：兰州交通大学化学化工学院，甘肃 兰州
关键词: 1；4-钯迁移；多取代烯烃；C-H功能化；1；4-Palladium Migration； Polysubstituted Alkenes； C-H Functionalization
摘要: 芳基到烯基的1,4-钯迁移反应是高效高选择性地实现远程烯烃C-H键活化功能化的重要策略之一，通过金属钯在分子内的可控迁移实现烯烃特定位置的选择性转化从而合成高立体选择性的多取代烯烃。近年来，随着新型配体设计和反应体系的开发，将这一策略串联各类偶联试剂，成功合成了一系列多取代烯烃，极大地拓展了其在有机合成中的应用范围。本文系统综述了芳基到烯基1,4-钯迁移反应与各类偶联试剂的串联反应进展，重点探讨了反应机理、选择性控制和合成应用，并指出了目前的难点及未来发展方向。
Abstract: The 1,4-palladium migration from an aryl to an alkenyl moiety represents a powerful and selective strategy for achieving remote functionalization of alkenes via C-H bond activation. This methodology leverages the controlled intramolecular migration of a palladium catalyst along a molecular scaffold to facilitate selective transformations at specific alkene positions, thereby enabling the stereoselective synthesis of complex, poly-substituted alkenes. Recent advancements, driven by innovations in ligand design and reaction system development, have seen the successful integration of this migration strategy with a diverse array of coupling partners. This tandem approach has considerably broadened the synthetic utility of 1,4-palladium migration, granting efficient access to a wide range of alkene architectures. This review provides a systematic overview of the progress in tandem reactions initiated by 1,4-palladium migration, with a particular emphasis on mechanistic insights, strategies for controlling regio- and stereoselectivity, and its growing applications in complex molecule synthesis. The current challenges and potential future directions in this field are also critically evaluated.
文章引用：武雅茹, 陈家乐, 孙文婷, 刘兆传, 王崔天, 樊晓辉. 芳基到烯基的1,4-钯迁移反应研究[J]. 化学工程与技术, 2025, 15(6): 333-346. https://doi.org/10.12677/hjcet.2025.156031

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