基于国医大师段富津豁痰宣痹理论的化痰通络颗粒治疗冠心病稳定型心绞痛(痰瘀互阻证)作用机制研究

Research on the Mechanism of Action of Huatan Tongluo Granules (Based on Master Physician Duan Fujin’s Theory of Resolving Phlegm and Unblocking Obstruction) in Treating Stable Angina Pectoris of Coronary Heart Disease (Syndrome of Phlegm-Stasis Intermingling)

摘要: 近年来，心血管疾病已成为全球健康的首要威胁，其中以冠心病稳定型心绞痛作为典型代表，发病率呈年轻化与普遍化趋势。现代医学认为其发病主要与冠状动脉粥样硬化导致的心肌氧供需求失衡有关，治疗以抗血小板聚集、血脂调控、血压管理及改善冠脉供血为主，但存在持续性差和不良反应等问题。中医则将其归类为“胸痹”范畴，认为病机为本虚标实、虚实夹杂，以气虚为本，痰浊、血瘀为标。基于国医大师段富津的豁痰宣痹理论，化痰通络颗粒在瓜蒌薤白半夏汤基础上化裁而来，兼顾祛痰化瘀与补气，通过多成分、多靶点的作用机制，有效改善冠心病稳定型心绞痛(痰瘀互阻证)的症状，为中医药治疗心血管疾病提供了新的思路和方法。

Abstract: In recent years, cardiovascular diseases have become a primary global health threat, with stable angina pectoris of Coronary Heart Disease (CHD) as a typical example showing a trend of increasing incidence among younger and broader populations. Modern medicine attributes its pathogenesis mainly to an imbalance between myocardial oxygen supply and demand caused by coronary atherosclerosis. Primary treatments include antiplatelet aggregation, lipid regulation, blood pressure management, and improving coronary blood supply. However, these approaches are often associated with issues such as poor adherence and adverse effects. In Traditional Chinese Medicine (TCM), this condition is categorized as ‘chest impediment’ (Xiong Bi). Its pathogenesis is considered a deficiency-excess complex, characterized by root deficiency and branch excess. Qi deficiency constitutes the root, while phlegm-turbidity and blood stasis form the branch manifestations. Based on the theory of expelling phlegm and diffusing chest impediment from Master of TCM Duan Fujin, Huatan Tongluo Granules are derived from the classic formula Gualou Xiebai Banxia Decoction. This formula simultaneously addresses the elimination of phlegm, dissolution of stasis, and supplementation of qi. Through a multi-component, multi-target mechanism of action, Huatan Tongluo Granules effectively alleviate symptoms in patients with stable angina pectoris of CHD (pattern of phlegm-stasis mutual obstruction). This provides a new perspective and methodology for treating cardiovascular diseases within the framework of TCM.