口腔溃疡治疗中金甲石愈疡方的临床效果评价与长期预防研究

Clinical Evaluation and Long-Term Prevention of Jin Jia Shi Healing Wound Formulain the Treatment of Oral Ulcer

摘要: 随着现代生活节奏的加快，人们饮食习惯的改变，及心理因素的作用，口腔溃疡成为一种常见病、多发病。长期以来，针对口腔溃疡的治疗多采用西医方法，但复发率高、治疗效果不理想的问题一直困扰着患者和医生。针对此问题，研究团队通过对金甲石愈疡方的中药配方进行深入研究，探讨其中药物成分针对口腔溃疡的治疗效果及预防复发的可能性。研究共纳入295例口腔溃疡患者，根据随机数字表法分为两组，实验组153例采用金甲石愈疡方治疗，对照组142例采用西医常规治疗。治疗周期均为4周，追踪观察12个月，评价两组患者的治疗效果及复发率。结果显示，实验组在治疗后即刻有效率达到92.81%，明显高于对照组的75.35%，且追踪期间实验组的复发率明显降低，与对照组相比差异具有统计学意义(P < 0.01)。实验组患者在治疗期间血清中炎症因子如CRP、TNF-α及IL-6的水平显著低于治疗前，提示金甲石愈疡方在调节免疫和减轻体内炎症反应中起到积极作用。此外，由于金甲石愈疡方在中药材来源、炮制流程、临床配伍等方面的规范化实践，使得其安全性得到保障，整体不良反应发生率低于5%。这一研究为中医药治疗复发性口腔溃疡提供了一种新途径，同时为中药在现代疾病中的应用开辟了新领域。据此，金甲石愈疡方在临床应用中展现出了优异的治疗效果及长期预防复发的潜力，证明其作为一种替代和补充治疗手段在口腔溃疡治疗中的实用价值。

Abstract: With the acceleration of modern life, changes in people’s dietary habits, and the influence of psychological factors, oral ulcers have become a common and frequently occurring disease. Traditionally, treatments for oral ulcers have mainly employed Western medicine approaches, but issues with high recurrence rates and less than ideal treatment outcomes have continued to be a concern for patients and doctors. In response to this issue, a research team conducted an in-depth study of the traditional Chinese medicine formula “Jin Jia Shi Healing Wound Formulain” exploring the potential of its medicinal components in treating oral ulcers and preventing recurrence. The study included 295 patients with oral ulcers, who were divided into two groups by random number table method: 153 patients in the experimental group were treated with“Jin Jia Shi Healing Wound Formulain”, and 142 patients in the control group received conventional Western medical treatment. The treatment period was 4 weeks for both groups, with a 12-month follow-up observation to evaluate the treatment effects and recurrence rates of the two groups. The results showed that the immediate effective rate of the experimental group after treatment reached 92.81%, which was significantly higher than the 75.35% of the control group. Moreover, during the follow-up period, the recurrence rate of the experimental group was significantly reduced, with a statistically significant difference compared to the control group (P < 0.01). Patients in the experimental group showed significantly lower levels of serum inflammatory factors such as CRP, TNF-α, and IL-6 during the treatment than before treatment, indicating that Jinjia Shiyu Fang plays an active role in regulating immunity and reducing internal inflammation. Additionally, due to the standardization of practice in aspects such as herbal material sources, processing procedures, and clinical compatibility, the safety of Jinjia Shiyu Fang has been ensured, with the overall incidence rate of adverse reactions being lower than 5%. This study provides a new approach for traditional Chinese medicine in the treatment of recurrent oral ulcers and opens up new frontiers for the application of Chinese medicine in modern diseases. Hence, Jinjia Shiyu Fang has shown excellent treatment effects and the potential for long-term prevention of recurrence in its clinical application, proving its practical value as an alternative and complementary therapeutic option in the treatment of oral ulcers.