PDRN在医学健康领域的研究与应用趋势
PDRN: Research and Application Trends in Medical and Health Field
DOI: 10.12677/hjbm.2025.156118, PDF,   
作者: 黄宇石*：成都岷山创芯生物芯片科技有限公司，四川 成都
关键词: 多聚脱氧核糖核苷酸；再生医学；组织修复；Polydeoxyribonucleotide； Regenerative Medicine； Tissue Repairing
摘要: 多聚脱氧核糖核苷酸(PDRN)是低分子量短链DNA片段，多来源于鱼类生殖细胞，不具备有意义的遗传信息，是近期中国再生医学与高端护肤品的热点研发对象。本综述梳理其腺苷受体激动剂、核酸补救合成促进组织再生的两大核心机制、讨论其在皮肤、关节、神经再生等领域的研究与应用现状，分析新产品开发的可能方向，探讨其转化应用仍面临的核心障碍，为PDRN更进一步的技术研发与产品开发提供参考。
Abstract: Polydeoxyribonucleotide (PDRN) is a short-chain DNA fragment with low molecular weight, mainly derived from fish sperms and without meaningful genetic information. It has recently become a research focus in regenerative medicine and high-end skincare products in China. This review combs through its two core mechanisms for promoting tissue regeneration-namely, acting as an adenosine receptor agonist and facilitating the salvage pathway of nucleic acids-discusses the current status of its research and application in fields such as skin, joint, and nerve regeneration, analyzes potential directions for the development of new products, and explores the core obstacles still faced in its translational application. This review provides references for further technological research and product development of PDRN.
文章引用：黄宇石. PDRN在医学健康领域的研究与应用趋势[J]. 生物医学, 2025, 15(6): 1095-1101. https://doi.org/10.12677/hjbm.2025.156118

参考文献

[1] Squadrito, F., Bitto, A., Irrera, N., Pizzino, G., Pallio, G., Minutoli, L., et al. (2017) Pharmacological Activity and Clinical Use of PDRN. Frontiers in Pharmacology, 8, Article 224. [Google Scholar] [CrossRef] [PubMed]
[2] Tonello, G., Daglio, M., Zaccarelli, N., Sottofattori, E., Mazzei, M. and Balbi, A. (1996) Characterization and Quantitation of the Active Polynucleotide Fraction (PDRN) from Human Placenta, a Tissue Repair Stimulating Agent. Journal of Pharmaceutical and Biomedical Analysis, 14, 1555-1560. [Google Scholar] [CrossRef] [PubMed]
[3] Thellung, S., Florio, T., Maragliano, A., Cattarini, G. and Schettini, G. (1999) Polydeoxyribonucleotides Enhance the Proliferation of Human Skin Fibroblasts: Involvement of A2 Purinergic Receptor Subtypes. Life Sciences, 64, 1661-1674. [Google Scholar] [CrossRef] [PubMed]
[4] Galeano, M., Bitto, A., Altavilla, D., Minutoli, L., Polito, F., Calò, M., et al. (2008) Polydeoxyribonucleotide Stimulates Angiogenesis and Wound Healing in the Genetically Diabetic Mouse. Wound Repair and Regeneration, 16, 208-217. [Google Scholar] [CrossRef] [PubMed]
[5] Irrera, N., Arcoraci, V., Mannino, F., Vermiglio, G., Pallio, G., Minutoli, L., et al. (2018) Activation of A2A Receptor by PDRN Reduces Neuronal Damage and Stimulates Wnt/β-Catenin Driven Neurogenesis in Spinal Cord Injury. Frontiers in Pharmacology, 9, Article 506. [Google Scholar] [CrossRef] [PubMed]
[6] Irrera, N., Bitto, A., Vaccaro, M., Mannino, F., Squadrito, V., Pallio, G., et al. (2020) PDRN, a Bioactive Natural Compound, Ameliorates Imiquimod-Induced Psoriasis through NF-κB Pathway Inhibition and Wnt/β-Catenin Signaling Modulation. International Journal of Molecular Sciences, 21, Article 1215. [Google Scholar] [CrossRef] [PubMed]
[7] Belletti, S., Uggeri, J., Gatti, R., Govoni, P. and Guizzardi, S. (2007) Polydeoxyribonucleotide Promotes Cyclobutane Pyrimidine Dimer Repair in UVB-Exposed Dermal Fibroblasts. Photodermatology, Photoimmunology & Photomedicine, 23, 242-249. [Google Scholar] [CrossRef] [PubMed]
[8] Oh, N., Hwang, J., Kang, M.S., Yoo, C., Kwak, M. and Han, D. (2025) Versatile and Marvelous Potentials of Polydeoxyribonucleotide for Tissue Engineering and Regeneration. Biomaterials Research, 29, Article 183. [Google Scholar] [CrossRef] [PubMed]
[9] Baek, A., Kim, M., Kim, S.H., Cho, S. and Kim, H.J. (2018) Anti-Inflammatory Effect of DNA Polymeric Molecules in a Cell Model of Osteoarthritis. Inflammation, 41, 677-688. [Google Scholar] [CrossRef] [PubMed]
[10] Kim, M.S., Cho, R.K. and In, Y. (2019) The Efficacy and Safety of Polydeoxyribonucleotide for the Treatment of Knee Osteoarthritis. Medicine, 98, e17386. [Google Scholar] [CrossRef] [PubMed]
[11] Yoon, S., Kang, J.J., Kim, J., Park, S. and Kim, J.M. (2019) Efficacy and Safety of Intra-Articular Injections of Hyaluronic Acid Combined with Polydeoxyribonucleotide in the Treatment of Knee Osteoarthritis. Annals of Rehabilitation Medicine, 43, 204-214. [Google Scholar] [CrossRef] [PubMed]
[12] Ko, I., Jin, J., Hwang, L., Kim, S., Kim, C., Jeon, J.W., et al. (2021) Adenosine A2A Receptor Agonist Polydeoxyribonucleotide Ameliorates Short-Term Memory Impairment by Suppressing Cerebral Ischemia-Induced Inflammation via MAPK Pathway. PLOS ONE, 16, e0248689. [Google Scholar] [CrossRef] [PubMed]
[13] Kim, S., Ko, I., Jin, J., Hwang, L., Kim, C., Kim, S., et al. (2020) Polydeoxyribonucleotide Exerts Therapeutic Effect by Increasing VEGF and Inhibiting Inflammatory Cytokines in Ischemic Colitis Rats. BioMed Research International, 2020, Article 2169083. [Google Scholar] [CrossRef] [PubMed]
[14] Squadrito, F., Bitto, A., Altavilla, D., Arcoraci, V., et al. (2014) The Effect of PDRN, an Adenosine Receptor A2A Agonist, on the Healing of Chronic Diabetic Foot Ulcers: Results of a Clinical Trial. The Journal of Clinical Endocrinology & Metabolism, 99, E746-E753.
[15] De Caridi, G., Massara, M., Acri, I., Zavettieri, S., Grande, R., Butrico, L., et al. (2016) Trophic Effects of Polynucleotides and Hyaluronic Acid in the Healing of Venous Ulcers of the Lower Limbs: A Clinical Study. International Wound Journal, 13, 754-758. [Google Scholar] [CrossRef] [PubMed]
[16] Kim, T.H., Kim, S.C., Park, W.S., Choi, I.W., et al. (2023) PCL/Gelatin Nanofibers Incorporated with Starfish Polydeoxyribonucleotides for Potential Wound Healing Applications. Materials & Design, 229, Article 111912. [Google Scholar] [CrossRef] 
[17] Lee, S., Zheng, Z., Kang, J., Kim, D., Oh, S.H. and Cho, S.B. (2015) Therapeutic Efficacy of Autologous Platelet-Rich Plasma and Polydeoxyribonucleotide on Female Pattern Hair Loss. Wound Repair and Regeneration, 23, 30-36. [Google Scholar] [CrossRef] [PubMed]
[18] Yun, Y.G., Yeo, D., Shin, S., Shin, J., Lee, J.H. and Kim, H. (2024) Polydeoxyribonucleotide Enhances the Bioactivities of Stem Cells from Human Exfoliated Deciduous Teeth through Akt Activation. Biochemical and Biophysical Research Communications, 739, Article 150947. [Google Scholar] [CrossRef] [PubMed]
[19] He, Y., Xu, L., Pei, X., Dong, Y. and Yang, X. (2025) Preparation of Polydeoxyribonucleotide Nanoliposomes and Their Applicability to Cosmetic Formulations. Current Pharmaceutical Biotechnology, 26. [Google Scholar] [CrossRef] [PubMed]
[20] Liu, Y., Hu, W., Pei, X., Zhu, J., Meng, H., Lyu, Y., et al. (2025) Polydeoxyribonucleotide-Spermidine Nanoparticles: Preparation, Characterization, and Verification of Skin Anti-Aging Efficacy. International Journal of Biological Macromolecules, 322, Article 146984. [Google Scholar] [CrossRef] [PubMed]
[21] Nguyen, T.H., Wang, S. and Nguyen, V.B. (2024) Recent Advances on Polydeoxyribonucleotide Extraction and Its Novel Application in Cosmeceuticals. International Journal of Biological Macromolecules, 282, Article 137051. [Google Scholar] [CrossRef] [PubMed]
[22] Lee, K., Lee, S., Wang, H., Lee, G., Kim, S., Ryu, Y., et al. (2023) Analysis of Skin Regeneration and Barrier-Improvement Efficacy of Polydeoxyribonucleotide Isolated from Panax Ginseng (C.A. Mey.) Adventitious Root. Molecules, 28, Article 7240. [Google Scholar] [CrossRef] [PubMed]
[23] Kim, T.H., Heo, S.Y., Han, J.S. and Jung, W.K. (2023) Anti‐Inflammatory Effect of Polydeoxyribonucleotides (PDRN) Extracted from Red Alga (porphyra sp.) (Ps‐PDRN) in RAW 264.7 Macrophages Stimulated with Escherichia coli Lipopolysaccharides: A Comparative Study with Commercial PDRN. Cell Biochemistry and Function, 41, 889-897. [Google Scholar] [CrossRef] [PubMed]
[24] Chae, D., Oh, S.W., Choi, Y.S., Kang, D.J., Park, C.W., Lee, J. and Seo, W.S. (2025) First Report on Microbial-Derived Polydeoxyribonucleotide: A Sustainable and Enhanced Alternative to Salmon-Based Polydeoxyribonucleotide. Current Issues in Molecular Biology, 47, Article 41. [Google Scholar] [CrossRef] [PubMed]

为你推荐