独角莲化学成分及抗肿瘤活性研究进展
Research Progress on Chemical Constituents and Antitumor Activity of Typhonium giganteum
DOI: 10.12677/tcm.2025.1411688, PDF,    科研立项经费支持
作者: 徐 迪*, 宋芳华#, 姜雪滨, 单丹妮：大连大学附属新华医院肿瘤内科，辽宁 大连
关键词: 独角莲；化学成分；抗肿瘤活性；Typhonium giganteum； Chemical Constituents； Antitumor Activity
摘要: 独角莲(Typhonium giganteum Engl.)作为我国传统药物体系中的重要药材，其干燥块茎在中药学中习称“白附子”。《神农本草经》明确记载其具有祛风化痰的核心功效，至今仍广泛应用于中风惊痫等神经性疾病的临床干预。近年药理学研究揭示，该药材富含结构多样的活性成分群，涵盖生物碱类、甾体化合物(典型如β-谷甾醇与菜油甾醇)、有机酸(包括棕榈酸、亚油酸等)以及糖脂类物质。尤其值得注意的是，大量实验证据支持其通过多重机制展现抗肿瘤潜力：既可诱导肿瘤细胞程序性死亡、抑制血管新生以阻断营养供给，又能阻碍肿瘤侵袭转移进程、破坏细胞骨架完整性，同时兼具免疫稳态调节与机体氧化防御增强等协同效应。本文系统梳理独角莲化学成分谱系及其抗肿瘤作用机制的最新研究进展，旨在为基于该药材的创新药物研发提供关键科学依据。
Abstract: Typhonium giganteum Engl. is a traditional Chinese medicinal herb. Its dried tuber is called “Rhizoma Typhonii”, which has the effects of dispelling wind and resolving phlegm and is commonly used in the treatment of stroke, epilepsy and other diseases. In recent years, studies have shown that Typhonium giganteum Engl. is rich in a variety of active chemical components, mainly including alkaloids, steroidal compounds (such as β-sitosterol and campesterol), organic acids (such as palmitic acid and linoleic acid) and glycolipid compounds. Typhonium giganteum Engl. has good anti-tumor potential, including inducing cell apoptosis, anti-tumor angiogenesis, inhibiting tumor invasion and metastasis, destroying the cytoskeleton of tumor cells, immunomodulation and enhancing the body’s antioxidant capacity. This paper reviews the progress of research on the chemical components and anti-tumor activity of Typhonium giganteum Engl., providing a scientific basis for the development of new drugs.
文章引用：徐迪, 宋芳华, 姜雪滨, 单丹妮. 独角莲化学成分及抗肿瘤活性研究进展[J]. 中医学, 2025, 14(11): 4776-4781. https://doi.org/10.12677/tcm.2025.1411688

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