组蛋白乳酸化修饰的作用机制及其在肿瘤中的研究进展
The Mechanisms and Research Advances of Histone Lactylation in Cancer
摘要: 乳酸作为肿瘤微环境中的重要代谢产物，在肿瘤发生发展和治疗中扮演着关键角色。组蛋白乳酸化修饰是近年来发现的一种新的蛋白质翻译后修饰，为代谢状态与表观遗传调控之间建立了直接联系。与此同时，越来越多的非组蛋白乳酸化靶点也被鉴定。现有研究表明，乳酸化修饰的酶学调控网络包括乳酸化酶(writers)、去乳酸化酶(erasers)及识别蛋白(readers)，但其具体作用机制仍需进一步阐明。在肿瘤中，乳酸化修饰参与免疫微环境调控、代谢重编程及血管生成等关键过程，与肿瘤细胞增殖、转移和耐药性密切相关。本文综述了组蛋白乳酸化修饰的作用机制及其在恶性肿瘤中的作用、以及肿瘤治疗中的潜力。
Abstract: As an important metabolite in the tumor microenvironment, lactic acid plays a key role in the development and treatment of tumors. Histone lactylation is a new protein post-translational modification discovered in recent years. It establishes a direct connection between cellular metabolic status and epigenetic regulation. In addition to histones, an increasing number of non-histone proteins have been identified to undergo lactylation. Current studies indicate that the enzymatic regulatory network of lactylation consists of lactyltransferases (writers), delactylases (erasers), and recognition proteins (readers), yet their specific molecular mechanisms remain incompletely understood. In cancer, lactylation is involved in the regulation of the immune microenvironment, metabolic reprogramming, and angiogenesis, thereby promoting tumor cell proliferation, metastasis, and therapeutic resistance. This review summarizes the research progress of the mechanism of histone lactylation, the role of histone lactylation in malignant tumors, and the potential of tumor therapy.
文章引用：唐允贞, 姜政. 组蛋白乳酸化修饰的作用机制及其在肿瘤中的研究进展[J]. 临床医学进展, 2025, 15(11): 911-918. https://doi.org/10.12677/acm.2025.15113175

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