高压氧对脑卒中后心脏功能保护作用的研究进展

Research Progress on the Cardioprotective Effect of Hyperbaric Oxygen Therapy after Cerebral Stroke

摘要: 脑卒中(Cerebral Stroke, CS)是一种高发病率、高致残率和高死亡率的脑血管疾病，严重威胁人类健康。CS除了引发神经系统损伤外，还可以通过“脑–心轴”机制影响心功能，诱发一系列心脏并发症，如心律失常、心肌损伤和心力衰竭等，进而影响患者的康复效果和远期预后。近年来，HBOT (Hyperbaric Oxygen Therapy, HBOT)作为辅助康复手段被广泛应用于CS患者中，其在改善心肌代谢、增强自主神经调节、促进微循环灌注以及抑制炎症反应等方面具有潜在益处，从而发挥心脏保护作用，进而改善CS恢复期患者的心功能状态。然而，当前尚缺乏针对CS恢复期心功能干预的高质量循证医学证据。本文综述近年来国内外关于HBOT在CS恢复期心功能改善中的研究进展，旨在为临床实践与后续研究提供理论基础与方向。

Abstract: Cerebral Stroke (CS) is a cerebrovascular disease characterized by high incidence, high disability rate, and high mortality, which poses a serious threat to human health. In addition to causing neurological damage, CS can also affect cardiac function through the “brain-heart axis” mechanism and induce a series of cardiac complications, such as arrhythmia, myocardial injury, and heart failure. These complications further impact the rehabilitation effect and long-term prognosis of patients. In recent years, Hyperbaric Oxygen Therapy (HBOT) has been widely used as an auxiliary rehabilitation method in CS patients. It has potential benefits in improving myocardial metabolism, enhancing autonomic nerve regulation, promoting microcirculatory perfusion, and inhibiting inflammatory responses, thereby exerting a cardioprotective effect and further improving the cardiac function of CS patients in the recovery period. However, there is still a lack of high-quality evidence-based medical evidence for cardiac function intervention in the recovery period of CS. This article reviews the research progress of HBOT in improving cardiac function during the recovery period of CS at home and abroad in recent years, aiming to provide a theoretical basis and direction for clinical practice and subsequent research.