围绝经期女性伴发抑郁状态的诊疗进展
Advances in the Diagnosis and Treatment of Depression in Perimenopausal Women
DOI: 10.12677/acm.2025.15113190, PDF,   
作者: 刘 婷, 熊正爱*:重庆医科大学附属第二医院妇产科,重庆
关键词: 围绝经期抑郁筛查诊断治疗激素Perimenopausal Depression Screening Diagnosis Treatment Hormone
摘要: 围绝经期是女性卵巢功能衰退的关键阶段,雌激素波动导致抑郁发生率显著升高。全球流行病学数据显示,围绝经期抑郁(Perimonopausal Depression, PMD)患病率为33.9% (95% CI: 27.8%~40.0%),我国门诊围绝经期女性抑郁症状检出率达37.9%。PMD不仅加重血管舒缩症状(VMS)及睡眠障碍,还与心血管疾病风险升高相关。世界卫生组织(WHO)将PMD列为中老年女性健康管理的优先领域,我国亦强调需关注PMD的早期识别。本文结合最新研究,从筛查、诊断、生物标志物及治疗策略方面综述。
Abstract: The perimenopausal period is a critical stage marked by the decline of ovarian function in women. Fluctuations in estrogen levels contribute to a significantly increased incidence of depression. Global epidemiological data indicate that the prevalence of perimenopausal depression (PMD) is 33.9% (95% CI: 27.8%~40.0%), with a detection rate of depressive symptoms reaching 37.9% among perimenopausal women in outpatient settings in China. PMD not only exacerbates vasomotor symptoms (VMS) and sleep disturbances but is also associated with an elevated risk of cardiovascular diseases. The World Health Organization (WHO) has identified PMD as a priority area for health management in middle-aged and older women, and China also emphasizes the need for early recognition of PMD. This article reviews the latest research, summarizing advances in screening, diagnosis, biomarkers, and treatment strategies for PMD.
文章引用:刘婷, 熊正爱. 围绝经期女性伴发抑郁状态的诊疗进展[J]. 临床医学进展, 2025, 15(11): 1045-1054. https://doi.org/10.12677/acm.2025.15113190

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