乳酸化修饰在脓毒症中的研究进展

Research Progress on Lactylation Modification in Sepsis

摘要: 脓毒症是一种由感染引起的全身性炎症反应综合征，近年来，乳酸化修饰作为一种新兴的后转录修饰方式，逐渐引起了研究者的广泛关注。脓毒症的发生和发展与机体的免疫反应和细胞代谢密切相关，而乳酸化修饰在这些过程中可能发挥重要作用。现有研究表明，乳酸化不仅影响细胞的代谢途径，还可能通过调控免疫细胞功能、细胞信号转导等机制参与脓毒症的病理生理过程。然而，目前关于乳酸化修饰在脓毒症中的具体机制和作用尚不明确，相关研究仍处于起步阶段。本文旨在综述乳酸化修饰在脓毒症中的最新研究进展，探讨其在免疫反应、细胞代谢及病理生理中的作用机制，并分析乳酸化修饰作为潜在治疗靶点的前景，为脓毒症的进一步研究提供新的视角和思路。

Abstract: Sepsis is a systemic inflammatory response syndrome triggered by infection. In recent years, lactylation modification, as an emerging post-translational modification, has garnered increasing attention from researchers. The onset and progression of sepsis are closely associated with the host’s immune response and cellular metabolism, and lactylation modification may play a significant role in these processes. Existing studies suggest that lactylation not only influences cellular metabolic pathways but may also be involved in the pathophysiological mechanisms of sepsis by regulating immune cell functions and cellular signal transduction. However, the specific mechanisms and roles of lactylation modification in sepsis remain unclear, and related research is still in its early stages. This article aims to review the latest research progress on lactylation modification in sepsis, explore its mechanisms in immune response, cellular metabolism, and pathophysiology, and analyze the potential of lactylation modification as a therapeutic target, thereby providing new perspectives and insights for further research on sepsis.