超声引导下闭孔神经关节支射频消融治疗慢性内侧髋关节疼痛:病例报告及文献研究
Ultrasound-Guided Radiofrequency Ablation of the Articular Branch of the Obturator Nerve for Chronic Medial Hip Pain: A Case Report and Literature Review
摘要: 背景:闭孔神经关节支射频消融术(Radiofrequency Ablation, RFA)是治疗非手术候选慢性内侧髋关节疼痛(Chronic Medial Hip Pain, CMHP)的常用手段,传统操作依赖透视或超声联合透视,单纯超声引导的相关研究匮乏。目的:评价超声引导下闭孔神经关节支RFA治疗CMHP的有效性与可行性。方法:纳入2例CMHP患者(1例股骨头缺血性坏死Ficat-Arlet IV期、1例髋关节骨关节炎Tonnis III期),术前以1%利多卡因2 mL行诊断性阻滞,48小时后行超声引导下RFA,术后随访3个月。结果:术后3个月,2例患者的NRS评分分别从基线8分、7分降至2分、0分;WOMAC评分分别从92分、72分降至33分、6分;镇痛药物用量减少,1例完全停用,无并发症。结论:在本研究纳入的2例患者中,超声引导下闭孔神经关节支RFA初步显示出一定的精准性、微创性及无辐射优势,可能适用于非手术候选CMHP患者,或对缓解疼痛、改善功能具有潜在帮助,但该技术的有效性与安全性仍需大样本、长期随访研究进一步验证。目前结论仅为探索性发现,不能推广至更广泛的人群。
Abstract: Background: Radiofrequency ablation (RFA) of the articular branches of the obturator nerve is a common approach for treating chronic medial hip pain (CMHP) in patients who are not candidates for surgery. Traditional procedures rely on fluoroscopy or a combination of ultrasound and fluoroscopy, while studies on ultrasound-guided RFA alone are scarce. Objective: To evaluate the effectiveness and feasibility of ultrasound-guided RFA of the articular branches of the obturator nerve in treating CMHP. Methods: Two patients with CMHP (one with Ficat-Arlet stage IV avascular necrosis of the femoral head and one with Tonnis stage III hip osteoarthritis) were included. A diagnostic block was performed with 2 mL of 1% lidocaine before surgery. Ultrasound-guided RFA was carried out 48 hours later, and the patients were followed up for 3 months post-operatively. Results: At 3 months post-operatively, the NRS scores of the two patients decreased from 8 and 7 at baseline to 2 and 0, respectively. The WOMAC scores dropped from 92 and 72 to 33 and 6, respectively. The dosage of analgesic medications was reduced, with one patient completely discontinuing the use. No complications occurred. Conclusion: In the two patients included in this study, ultrasound-guided RFA of the articular branches of the obturator nerve initially showed certain advantages of accuracy, minimal invasiveness and no radiation. It may be suitable for non-surgical CMHP patients and may have potential help in relieving pain and improving function. However, the effectiveness and safety of this technology still need to be further verified by large-sample and long-term follow-up studies. At present, the conclusions are only exploratory findings and cannot be extended to a wider population.
文章引用:李路明, 顾俊, 唐卉, 何中灿, 段越华. 超声引导下闭孔神经关节支射频消融治疗慢性内侧髋关节疼痛:病例报告及文献研究[J]. 亚洲外科手术病例研究, 2025, 13(1): 1-12. https://doi.org/10.12677/acrs.2025.131001

参考文献

[1] Bhatia, A., Hoydonckx, Y., Peng, P. and Cohen, S.P. (2018) Radiofrequency Procedures to Relieve Chronic Hip Pain: An Evidence-Based Narrative Review. Regional Anesthesia and Pain Medicine, 43, 72-83. [Google Scholar] [CrossRef] [PubMed]
[2] Kolasinski, S.L., Neogi, T., Hochberg, M.C., Oatis, C., Guyatt, G., Block, J., et al. (2020) 2019 American College of Rheumatology/Arthritis Foundation Guideline for the Management of Osteoarthritis of the Hand, Hip, and Knee. Arthritis & Rheumatology, 72, 220-233. [Google Scholar] [CrossRef] [PubMed]
[3] Ahuja, V., Thapa, D., Patial, S., Chander, A. and Ahuja, A. (2020) Chronic Hip Pain in Adults: Current Knowledge and Future Prospective. Journal of Anaesthesiology Clinical Pharmacology, 36, 450-457. [Google Scholar] [CrossRef] [PubMed]
[4] Forlenza, E.M., Nam, D., Fillingham, Y.A., et al. (2025) Pain Management in Total Hip and Knee Arthroplasty: Evidence-Based and Controversial Practices in 2024. Instructional Course Lectures, 74, 301-310.
[5] Choi, W., Hwang, S., Song, J., Leem, J., Kang, Y., Park, P., et al. (2011) Radiofrequency Treatment Relieves Chronic Knee Osteoarthritis Pain: A Double-Blind Randomized Controlled Trial. Pain, 152, 481-487. [Google Scholar] [CrossRef] [PubMed]
[6] Hunter, D.J., McDougall, J.J. and Keefe, F.J. (2008) The Symptoms of Osteoarthritis and the Genesis of Pain. Rheumatic Disease Clinics of North America, 34, 623-643. [Google Scholar] [CrossRef] [PubMed]
[7] Tinnirello, A., Todeschini, M., Pezzola, D., et al. (2018) Pulsed Radiofrequency Application on Femoral and Obturator Nerves for Hip Joint Pain: Retrospective Analysis with 12-Month Follow-Up Results. Pain Physician, 1, 407-414. [Google Scholar] [CrossRef
[8] Cheney, C.W., Ahmadian, A., Brennick, C., Zheng, P., Mattie, R., McCormick, Z.L., et al. (2021) Radiofrequency Ablation for Chronic Hip Pain: A Comprehensive, Narrative Review. Pain Medicine, 22, S14-S19. [Google Scholar] [CrossRef] [PubMed]
[9] Kallas, O.N., Nezami, N., Singer, A.D., Wong, P., Kokabi, N., Bercu, Z.L., et al. (2022) Cooled Radiofrequency Ablation for Chronic Joint Pain Secondary to Hip and Shoulder Osteoarthritis. RadioGraphics, 42, 594-608. [Google Scholar] [CrossRef] [PubMed]
[10] Guven Kose, S., Kose, H.C., Celikel, F. and Akkaya, O.T. (2022) Ultrasound-Guided Caudal Epidural Pulsed Radiofrequency for the Treatment of Failed Back Surgery Syndrome: Results of a Prospective Clinical Study. Interventional Pain Medicine, 1, Article 100145. [Google Scholar] [CrossRef] [PubMed]
[11] Hofmeister, M., Dowsett, L.E., Lorenzetti, D.L. and Clement, F. (2019) Ultrasound-Versus Fluoroscopy-Guided Injections in the Lower Back for the Management of Pain: A Systematic Review. European Radiology, 29, 3401-3409. [Google Scholar] [CrossRef] [PubMed]
[12] Petroni, G.M., Cofini, V., Necozione, S., De Sanctis, F., Commissari, R., Nazzarro, E., et al. (2024) Hip Chronic Pain: Ultrasound Guided Ablation of Anterior Articular Branches Plus Posterior Neurolysis of the Nerve to the Quadratus Femoris versus the Alone Anterior Approach—A Retrospective Observational Study. Journal of Ultrasound, 27, 545-550. [Google Scholar] [CrossRef] [PubMed]
[13] Jordan, J.M., Helmick, C.G., Renner, J.B., Luta, G., Dragomir, A.D., Woodard, J., et al. (2009) Prevalence of Hip Symptoms and Radiographic and Symptomatic Hip Osteoarthritis in African Americans and Caucasians: The Johnston County Osteoarthritis Project. The Journal of Rheumatology, 36, 809-815. [Google Scholar] [CrossRef] [PubMed]
[14] Sencan, S., Saçaklıdır, R. and Gunduz, O.H. (2024) Fluoroscopy-Guided Triple Hip Block for Patients with Hip Osteoarthritis: A New Approach. Ağrı-The Journal of The Turkish Society of Algology, 36, 120-122. [Google Scholar] [CrossRef] [PubMed]
[15] Tran, J., Peng, P.W.H., Lam, K., Baig, E., Agur, A.M.R. and Gofeld, M. (2018) Anatomical Study of the Innervation of Anterior Knee Joint Capsule: Implication for Image-Guided Intervention. Regional Anesthesia and Pain Medicine, 43, 407-414. [Google Scholar] [CrossRef] [PubMed]
[16] Tomlinson, J., Ondruschka, B., Prietzel, T., Zwirner, J. and Hammer, N. (2021) A Systematic Review and Meta-Analysis of the Hip Capsule Innervation and Its Clinical Implications. Scientific Reports, 11, Article No. 5299. [Google Scholar] [CrossRef] [PubMed]
[17] Nagpal, A.S., Brennick, C., Occhialini, A.P., Leet, J.G., Clark, T.S., Rahimi, O.B., et al. (2021) Innervation of the Posterior Hip Capsule: A Cadaveric Study. Pain Medicine, 22, 1072-1079. [Google Scholar] [CrossRef] [PubMed]
[18] Laumonerie, P., Dalmas, Y., Tibbo, M.E., Robert, S., Durant, T., Caste, T., et al. (2021) Sensory Innervation of the Hip Joint and Referred Pain: A Systematic Review of the Literature. Pain Medicine, 22, 1149-1157. [Google Scholar] [CrossRef] [PubMed]
[19] Barnett, J.J.G., Shakeri, S. and Agur, A.M.R. (2021) Overview of the Innervation of the Hip Joint. Physical Medicine and Rehabilitation Clinics of North America, 32, 745-755. [Google Scholar] [CrossRef] [PubMed]
[20] Birnbaum, K., Prescher, A., Heßler, S. and Heller, K. (1997) The Sensory Innervation of the Hip Joint—An Anatomical Study. Surgical and Radiologic Anatomy, 19, 371-375. [Google Scholar] [CrossRef] [PubMed]
[21] Sag, A.A. and Patel, P. (2022) CT-Guided Cooled Radiofrequency Denervation for Chronic Arthritis Pain of the Hip and Shoulder. Seminars in Interventional Radiology, 39, 150-156. [Google Scholar] [CrossRef] [PubMed]
[22] Heywang-Köbrunner, S.H., Amaya, B., Okoniewski, M., Pickuth, D. and Spielmann, R. (2001) CT-Guided Obturator Nerve Block for Diagnosis and Treatment of Painful Conditions of the Hip. European Radiology, 11, 1047-1053. [Google Scholar] [CrossRef] [PubMed]
[23] Gonzalez, F.M., Huang, J. and Fritz, J. (2023) Image-Guided Radiofrequency Ablation for Joint and Back Pain: Rationales, Techniques, and Results. CardioVascular and Interventional Radiology, 46, 1538-1550. [Google Scholar] [CrossRef] [PubMed]
[24] Fabris, L.K., Maretic, S.Z., Petrinovic, M., et al. (2023) Minimally Invasive Diagnostic Block and Percutaneous Radiofrequency Ablation in the Treatment of Chronic Hip Pain-Review Article. Acta Clinica Croatica, 62, 68-76.
[25] Kwun-Tung Ng, T., Chan, W., Peng, P.W.H., Sham, P., Sasaki, S. and Tsui, H. (2020) Chemical Hip Denervation for Inoperable Hip Fracture. Anesthesia & Analgesia, 130, 498-504. [Google Scholar] [CrossRef] [PubMed]
[26] Kapural, L., Jolly, S., Mantoan, J., et al. (2018) Cooled Radiofrequency Neurotomy of the Articular Sensory Branches of the Obturator and Femoral Nerves-Combined Approach Using Fluoroscopy and Ultrasound Guidance: Technical Report, and Observational Study on Safety and Efficacy. Pain Physician, 1, 279-284. [Google Scholar] [CrossRef
[27] Locher, S., Burmeister, H., Böhlen, T., Eichenberger, U., Stoupis, C., Moriggl, B., et al. (2008) Radiological Anatomy of the Obturator Nerve and Its Articular Branches: Basis to Develop a Method of Radiofrequency Denervation for Hip Joint Pain. Pain Medicine, 9, 291-298. [Google Scholar] [CrossRef] [PubMed]
[28] Sakamoto, J., Manabe, Y., Oyamada, J., Kataoka, H., Nakano, J., Saiki, K., et al. (2018) Anatomical Study of the Articular Branches Innervated the Hip and Knee Joint with Reference to Mechanism of Referral Pain in Hip Joint Disease Patients. Clinical Anatomy, 31, 705-709. [Google Scholar] [CrossRef] [PubMed]
[29] Malik, A., Simopolous, T., Elkers, H.M., et al. (2003) Percutaneous Radiofrequency Lesioning of Sensory Branches of the Obturator and Femoral Nerves for the Treatment of Non-Operable Hip Pain. Pain Physician, 4, 499-502. [Google Scholar] [CrossRef
[30] Tran, A., Reiter, D., Wong, P.K., Fritz, J., Cruz, A.R., Oskouei, S., et al. (2022) Alternative Treatment of Hip Pain from Advanced Hip Osteoarthritis Utilizing Cooled Radiofrequency Ablation: Single Institution Pilot Study. Skeletal Radiology, 51, 1047-1054. [Google Scholar] [CrossRef] [PubMed]
[31] Kumar, P., Hoydonckx, Y. and Bhatia, A. (2019) A Review of Current Denervation Techniques for Chronic Hip Pain: Anatomical and Technical Considerations. Current Pain and Headache Reports, 23, Article No. 38. [Google Scholar] [CrossRef] [PubMed]
[32] Pressler, M.P., Renwick, C., Lawson, A., Singla, P., Wahezi, S.E. and Kohan, L.R. (2024) Radiofrequency Ablation of the Hip: Review. Annals of Palliative Medicine, 13, 927-937. [Google Scholar] [CrossRef] [PubMed]
[33] Naber, J., Lee, N. and Kapural, L. (2019) Clinical Efficacy Assessment of Cooled Radiofrequency Ablation of the Hip in Patients with Avascular Necrosis. Pain Management, 9, 355-359. [Google Scholar] [CrossRef] [PubMed]
[34] Matchett, G. and Stone, J. (2014) Combined Ultrasound and Fluoroscopic Guidance for Radiofrequency Ablation of the Obturator Nerve for Intractable Cancerassociated Hip Pain. Pain Physician, 17, E83-E87. [Google Scholar] [CrossRef
[35] Kapural, L., Naber, J., Neal, K., et al. (2021) Cooled Radiofrequency Ablation of the Articular Sensory Branches of the Obturator and Femoral Nerves Using Fluoroscopy and Ultrasound Guidance: A Large Retrospective Study. Pain Physician, 24, E611-E617.
[36] Karaoğlu, S.Ş., Sari, S., Ekin, Y., Özkan, Y. and Aydin, O.N. (2024) The Effect of Conventional Radiofrequency Thermocoagulation of Femoral and Obturator Nerves’ Articular Branches on Chronic Hip Pain: A Prospective Clinical Study. Pain Medicine, 25, 444-450. [Google Scholar] [CrossRef] [PubMed]
[37] Jadon, A. (2021) Pulsed Radiofrequency (PRF) of Pericapsular Nerves Group (PENG) in Chronic Hip Pain—A Case Report. Turkish Journal of Anaesthesiology and Reanimation, 49, 490-493. [Google Scholar] [CrossRef] [PubMed]
[38] Khan, J.S., Krane, E.J., Higgs, M., Pritzlaff, S., Hoffinger, S. and Ottestad, E. (2019) A Case Report of Combined Ultrasound and Fluoroscopic-Guided Percutaneous Radiofrequency Lesioning of the Obturator and Femoral Articular Branches in the Treatment of Persistent Hip Pain in a Pediatric Patient. Pain Practice, 19, 52-56. [Google Scholar] [CrossRef] [PubMed]
[39] Correia, R., Oliveira, L., Andrade, I., Castro Correia, M.D., Gonçalves, E., Borges, A., et al. (2024) Ultrasound-Guided Radiofrequency Ablation for Chronic Hip Pain Due to Osteoarthritis. Cureus, 16, e53743. [Google Scholar] [CrossRef] [PubMed]
[40] Chaiban, G., Paradis, T. and Atallah, J. (2013) Use of Ultrasound and Fluoroscopy Guidance in Percutaneous Radiofrequency Lesioning of the Sensory Branches of the Femoral and Obturator Nerves. Pain Practice, 14, 343-345. [Google Scholar] [CrossRef] [PubMed]