氟西汀联合奥昔布宁对肺癌合并焦虑障碍患者的精神症状与生活质量的改善作用研究

A Study on the Improvement of Psychiatric Symptoms and Quality of Life in Patients with Lung Cancer and Anxiety Disorder with Fluoxetine and Oxybutynin

摘要: 目的：探讨氟西汀联合奥昔布宁对肺癌合并焦虑障碍患者精神症状与生活质量的改善作用及安全性。方法：选取2023年1月~2024年1月在本院收治的肺癌合并焦虑障碍患者60例，采用随机数字表法分为研究组与对照组，各30例。对照组提供氟西汀单药治疗，研究组在此基础上加用奥昔布宁，疗程均为12周。对比一般肺癌患者精神症状、生活质量、不良反应发生状况。结果：干预前，两组HADS-A、HADS-D及QLQ-C30评分比较差异无统计学意义(P > 0.05)；干预12周后，研究组HADS-A、HADS-D评分均显著低于对照组(P < 0.05)，QLQ-C30总体健康状况评分显著高于对照组(P < 0.05)。研究组不良反应发生率为16.67% (5/30)，对照组为13.33% (4/30)，差异无统计学意义(P > 0.05)。结论：氟西汀联合奥昔布宁可有效改善肺癌合并焦虑障碍患者的精神症状，提升生活质量，且安全性良好，值得推广。

Abstract: Objective: To explore the efficacy and safety of fluoxetine combined with oxybutynin in improving mental symptoms and quality of life of patients with lung cancer complicated with anxiety disorder. Methods: Sixty patients with lung cancer complicated with anxiety disorder admitted to our hospital from January 2023 to January 2024 were randomly divided into a study group and a control group, with 30 cases in each group. The control group was given fluoxetine alone, and the study group was given oxybutynin on the basis of it. The course of treatment was 12 weeks. To compare the mental symptoms, quality of life and adverse reactions of general lung cancer patients. Results: Before the intervention, there was no significant difference in the scores of HADS-A, HADS-D and QLQ-C30 between the two groups (P > 0.05). After 12 weeks of intervention, the HADS-A and HADS-D scores of the study group were significantly lower than those of the control group (P < 0.05), and the overall health status score of QLQ-C30 was significantly higher than that of the control group (P < 0.05). The incidence of adverse reactions was 16.67% (5/30) in the study group and 13.33% (4/30) in the control group, with no statistical significance (P > 0.05). Conclusion: Fluoxetine combined with oxybutynin can effectively improve the mental symptoms and improve the quality of life of patients with lung cancer complicated with anxiety disorder, and it is safe and worth popularizing.