基于“阳化气，阴成形”探讨线粒体自噬对动脉粥样硬化的影响

To Explore the Influence of Mitochondrial Autophagy on Atherosclerosis Based on “Yang Transforms Qi and Yin Constitutes Form”

摘要: 动脉粥样硬化(AS)是一种常见的血管疾病，是冠心病、脑卒中等血管疾病的主要致病因素。线粒体自噬是维持细胞内环境稳态的基石，也是维持细胞线粒体健康的关键机制，在生理和病理生理环境中均发挥着重要作用。中医认为AS为本虚标实之证，“阳化气，阴成形”为其关键病机。线粒体自噬遵循“阳化气，阴成形”的内在逻辑。阳化气不及，线粒体自噬不足，则降解、清除功能失常，致阴成形太过，病理产物异常积聚，气血阻滞，脉道不利，促进AS。现代研究证明，中药能多靶点、多通路调控线粒体自噬，故本文基于“阳化气，阴成形”理论，探讨线粒体自噬在动脉粥样硬化中的作用机制，以及通过中药以及复方干预，为中医药防治动脉粥样硬化提供新的思路。

Abstract: Atherosclerosis (AS) is a common vascular disease, which is the main pathogenic factor of coronary heart disease and stroke. Mitochondrial autophagy is the cornerstone of maintaining the homeosty of the intracellular environment, and it is also a key mechanism for maintaining the health of cellular mitochondria. It plays an important role in both physiological and pathophysiological environments. Traditional Chinese medicine believes that AS is the proof of the false standard, and “Yang Transforms Qi and Yin Constitutes Form” is its key pathology. Mitochondrial autophagy follows the inherent logic of “yang gas, yin formation”. If the yang qi is not enough and the mitochondrial autophagy is insufficient, the degradation and removal function will be abnormal, resulting in excessive yin formation, abnormal accumulation of pathological products, qi and blood blockage, unfavorable veins, and promoting AS. Modern research proves that traditional Chinese medicine can regulate mitochondrial autophagy with multiple targets and multiple channels. Therefore, this article explores the mechanism of mitochondrial autophagy in atherosclerosis based on the theory of “Yang Transforms Qi and Yin Constitutes Form”, and provides new ideas for the prevention and treatment of atherosclerosis through traditional Chinese medicine and compound intervention.