PRP治疗膝骨关节炎的研究进展
Research Progress on Platelet-Rich Plasma (PRP) Therapy for Knee Osteoarthritis
DOI: 10.12677/acm.2025.15113259, PDF,   
作者: 周佳蒨：右江民族医学院研究生学院，广西 百色；杨大伟*：右江民族医学院附属医院健康管理中心，广西 百色
关键词: 膝骨关节炎；PRP；治疗；联合治疗；疗效对比；Knee Osteoarthritis； PRP； Therapy； Combination Therapy； Efficacy Comparison
摘要: 膝骨关节炎(KOA)是一种以膝关节软骨退变、关节边缘骨赘形成及周围软组织炎症为特征的慢性退行性关节疾病，显著降低患者的生活质量。PRP (platelet rich plasma，富血小板血浆)作为一种自体源性生物治疗剂，在KOA治疗中展现出广阔前景。笔者在临床应用中观察到，PRP注射后部分患者可能出现一过性疼痛反应，但其中长期随访显示出的软骨修复与功能改善效果显著，这一“先扬后抑”的疗效模式值得深入探讨。本文旨在结合临床实践，综述PRP单独及联合其他疗法的临床效果，并分析其疗效差异背后的可能机制与临床应用优化策略。
Abstract: Knee osteoarthritis (KOA) is a chronic degenerative joint disease characterized by the deterioration of knee articular cartilage, the formation of osteophytes at the joint margins, and inflammation of the surrounding soft tissues, significantly reducing patients’ quality of life. Platelet-rich plasma (PRP), as an autologous biological therapeutic agent, shows great promise in the treatment of KOA. In clinical practice, the author has observed that while some patients may experience transient pain reactions following PRP injection, significant cartilage repair and functional improvement are demonstrated in medium- to long-term follow-up. This “initial flare-up followed by substantial improvement” efficacy pattern warrants in-depth investigation. This article aims to review the clinical outcomes of PRP both as a standalone treatment and in combination with other therapies, based on clinical experience, and to analyze the potential mechanisms behind the variability in efficacy and strategies for optimizing its clinical application.
文章引用：周佳蒨, 杨大伟. PRP治疗膝骨关节炎的研究进展[J]. 临床医学进展, 2025, 15(11): 1586-1592. https://doi.org/10.12677/acm.2025.15113259

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