miRNA在慢性前列腺炎中的研究进展：分子机制与临床应用展望
Research Progress of miRNA in Chronic Prostatitis: Molecular Mechanisms and Prospects for Clinical Application
摘要: 慢性前列腺炎/慢性盆腔疼痛综合征(Chronic Prostatitis/Chronic Pelvic Pain Syndrome, CP/CPPS)是泌尿外科中常见的慢性炎症性疾病之一，以慢性盆腔疼痛及下尿路症状(LUTS)为主要临床表现，部分患者伴随性功能障碍及相关神经精神症状，其病因复杂且临床治疗效果不理想，严重影响了男性患者生活质量。MicroRNA (miRNA)是近年来发现的参与调控大部分基因表达的重要因子，在CP/CPPS的发病机制及临床诊断治疗中备受关注。本文综述了近年来miRNA在CP/CPPS中的研究进展，探讨miRNA作为生物标志物在CP/CPPS临床诊疗中的作用，为CP/CPPS的诊疗提供理论依据和思路。
Abstract: Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is one of the common chronic inflammatory diseases in the field of urology, which is mainly manifested by chronic pelvic pain and lower urinary tract symptoms (LUTS), Some patients also suffer from sexual dysfunction and related neuropsychiatric symptoms. It has a large impact on the quality of life of the patient because of its complex etiology and poor clinical efficacy. MicroRNA (miRNA) is an important factor discovered in recent years that participates in the regulation of most gene expressions, and has garnered significant attention in the pathogenesis, clinical diagnosis, and treatment of CP/CPPS. This article reviews the recent research progress of miRNA in CP/CPPS, explores the role of miRNA as a biomarker in the clinical diagnosis and treatment of CP/CPPS, and provides a theoretical basis and ideas for the diagnosis and treatment of CP/CPPS.
文章引用：王粤斌, 余盛鑫, 温东, 帅歌柳, 石珍银, 曾雪晴, 邹晓峰. miRNA在慢性前列腺炎中的研究进展：分子机制与临床应用展望[J]. 临床医学进展, 2025, 15(11): 1617-1624. https://doi.org/10.12677/acm.2025.15113263

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