中医药调控相关信号通路治疗自身免疫性甲状腺疾病的研究进展
Research Progress on Traditional Chinese Medicine Regulating Related Signaling Pathways in the Treatment of Autoimmune Thyroid Diseases
DOI: 10.12677/acm.2025.15113291, PDF,   
作者: 刘勇麟：黑龙江中医药大学第一临床医学院，黑龙江 哈尔滨；刘影哲*：黑龙江中医药大学附属第一医院，内分泌一科，黑龙江 哈尔滨
关键词: 中医药；自身免疫性甲状腺疾病；信号通路；Traditional Chinese Medicine； Autoimmune Thyroid Diseases； Signaling Pathways
摘要: 自身免疫性甲状腺疾病(Autoimmune Thyroid Diseases, AITD)是一类涉及多种因素的复杂免疫性疾病，包括遗传易感性、环境因素、免疫系统障碍等。而中医药能够有效调节AITD发病相关的信号通路JAK/STAT、NLRP3/Caspase-1、NF-κB等，起到了减轻AITD患者的炎症反应和自身免疫损伤的作用，其在治疗过程中显示出多成分、多靶点的特点，为AITD的治疗提供了新的视角和方法。本文就中医药调控相关信号通路治疗AITD进行了综述，以期为今后的临床治疗和相关基础研究提供思路。
Abstract: Autoimmune thyroid diseases (AITD) are complex immune disorders involving multiple factors, including genetic susceptibility, environmental triggers, and immune system dysfunction. Traditional Chinese Medicine (TCM) can effectively regulate key signaling pathways implicated in AITD pathogenesis, such as JAK/STAT, NLRP3/Caspase-1, and NF-κB. By modulating these pathways, TCM alleviates inflammatory responses and autoimmune damage in AITD patients. TCM exhibits characteristics of being multicomponent and multitarget during its therapeutic action, offering novel perspectives and approaches for AITD treatment. This review summarizes the current research on TCM regulation of these relevant signaling pathways in the treatment of AITD, aiming to provide insights for future clinical management and related fundamental research.
文章引用：刘勇麟, 刘影哲. 中医药调控相关信号通路治疗自身免疫性甲状腺疾病的研究进展[J]. 临床医学进展, 2025, 15(11): 1847-1853. https://doi.org/10.12677/acm.2025.15113291

参考文献

[1] Vargas-Uricoechea, H. (2023) Molecular Mechanisms in Autoimmune Thyroid Disease. Cells, 12, Article 918. [Google Scholar] [CrossRef] [PubMed]
[2] Bogusławska, J., Godlewska, M., Gajda, E. and Piekiełko-Witkowska, A. (2021) Cellular and Molecular Basis of Thyroid Autoimmunity. European Thyroid Journal, 11, e210024. [Google Scholar] [CrossRef] [PubMed]
[3] Lee, H.J., Li, C.W., Hammerstad, S.S., Stefan, M. and Tomer, Y. (2015) Immunogenetics of Autoimmune Thyroid Diseases: A Comprehensive Review. Journal of Autoimmunity, 64, 82-90. [Google Scholar] [CrossRef] [PubMed]
[4] Antonelli, A., Ferrari, S.M., Corrado, A., Di Domenicantonio, A. and Fallahi, P. (2015) Autoimmune Thyroid Disorders. Autoimmunity Reviews, 14, 174-180. [Google Scholar] [CrossRef] [PubMed]
[5] 张艳, 谢敏, 左新河, 等. 中医药干预自身免疫性甲状腺疾病Th17/Treg平衡的研究进展[J]. 中国实验方剂学杂志, 2021, 27(10): 231-238.
[6] Zhou, L., Luo, J., Sun, A., Yang, H., Lin, Y. and Han, L. (2024) Clinical Efficacy and Molecular Mechanism of Chinese Medicine in the Treatment of Autoimmune Thyroiditis. Journal of Ethnopharmacology, 323, Article 117689. [Google Scholar] [CrossRef] [PubMed]
[7] Park, E.S., Kim, H., Suh, J.M., Park, S.J., You, S.H., Chung, H.K., et al. (2000) Involvement of JAK/STAT (Janus Kinase/Signal Transducer and Activator of Transcription) in the Thyrotropin Signaling Pathway. Molecular Endocrinology, 14, 662-670. [Google Scholar] [CrossRef] [PubMed]
[8] Davies, T.F., Andersen, S., Latif, R., Nagayama, Y., Barbesino, G., Brito, M., et al. (2020) Graves’ Disease. Nature Reviews Disease Primers, 6, Article No. 52. [Google Scholar] [CrossRef] [PubMed]
[9] Brand, O.J. and Gough, S.C.L. (2010) Genetics of Thyroid Autoimmunity and the Role of the TSHR. Molecular and Cellular Endocrinology, 322, 135-143. [Google Scholar] [CrossRef] [PubMed]
[10] Huang, Y., Wang, H., Chen, Z., Wang, Y., Qin, K., Huang, Y., et al. (2019) Synergistic and Hepatoprotective Effect of Total Glucosides of Paeony on Ankylosing Spondylitis: A Systematic Review and Meta-Analysis. Frontiers in Pharmacology, 10, Article 231. [Google Scholar] [CrossRef] [PubMed]
[11] 余欣然, 陈云志, 牧亚峰. 白芍总苷对自身免疫性甲状腺炎大鼠的免疫调节作用[J]. 中成药, 2023, 45(5): 1666-1669.
[12] 劳梓滢, 蒋智锐, 张靖怡, 等. 小柴胡汤化学成分、药理作用研究进展及质量标志物(Q-marker)预测[J]. 中草药, 2023, 54(19): 6520-6530.
[13] Du, P., Xu, J., Jiang, Y., Zhao, J., Gao, C., Fang, Y., et al. (2022) Saikosaponin-d Attenuates Hashimoto’s Thyroiditis by Regulating Macrophage Polarization. Journal of Immunology Research, 2022, 1-12. [Google Scholar] [CrossRef] [PubMed]
[14] 董天娇, 张兰, 刘佳, 等. 软坚消瘿颗粒对肝郁脾虚型桥本甲状腺炎大鼠作用机制的代谢组学分析[J]. 时珍国医国药, 2021, 32(5): 1104-1108.
[15] 王琳, 张兰, 许可, 等. 基于SOCS13JAK-STATS信号通路探讨软坚消瘿颗粒治疗肝郁脾虚型桥本甲状腺炎模型大鼠的实验研究[J]. 中华中医药学刊, 2023, 41(4): 251-254+301.
[16] Broz, P. and Dixit, V.M. (2016) Inflammasomes: Mechanism of Assembly, Regulation and Signalling. Nature Reviews Immunology, 16, 407-420. [Google Scholar] [CrossRef] [PubMed]
[17] Kelley, N., Jeltema, D., Duan, Y. and He, Y. (2019) The NLRP3 Inflammasome: An Overview of Mechanisms of Activation and Regulation. International Journal of Molecular Sciences, 20, Article 3328. [Google Scholar] [CrossRef] [PubMed]
[18] Guo, Q., Wu, Y., Hou, Y., Liu, Y., Liu, T., Zhang, H., et al. (2018) Cytokine Secretion and Pyroptosis of Thyroid Follicular Cells Mediated by Enhanced NLRP3, NLRP1, NLRC4, and AIM2 Inflammasomes Are Associated with Autoimmune Thyroiditis. Frontiers in Immunology, 9, Article 1197. [Google Scholar] [CrossRef] [PubMed]
[19] Ding, H., Sun, X. and Xu, H. (2023) Pharmacological Suppression of NLRP3 Inflammasome Attenuated the Development of Autoimmune Thyroiditis. Cellular Immunology, 384, Article 104659. [Google Scholar] [CrossRef] [PubMed]
[20] Long, S.F., He, T.F., Wu, D., Yang, M. and Piao, X.S. (2020) Forsythia Suspensa Extract Enhances Performance via the Improvement of Nutrient Digestibility, Antioxidant Status, Anti-Inflammatory Function, and Gut Morphology in Broilers. Poultry Science, 99, 4217-4226. [Google Scholar] [CrossRef] [PubMed]
[21] 栗粟, 陈红跃, 樊艳, 等. 连翘提取物对实验性自身免疫性甲状腺炎大鼠甲状腺损伤的影响[J]. 中国免疫学杂志, 2023, 39(5): 978-982.
[22] 赵卓, 宋囡, 刘子玉, 等. 补中益气汤对AIT小鼠Th17/Treg免疫失衡及Notch1信号通路的影响[J]. 中国实验方剂学杂志, 2024, 30(5): 19-27.
[23] 王智民, 杨潇, 陈怡然, 等. 基于NLRP3/Caspase-1/GSDMD通路探讨补中益气汤干预NOD.H-2h4小鼠AIT细胞焦亡的机制[J]. 中国实验方剂学杂志, 2024, 30(12): 8-15.
[24] Williams, L.M. and Gilmore, T.D. (2020) Looking down on NF-κB. Molecular and Cellular Biology, 40, e00104. [Google Scholar] [CrossRef] [PubMed]
[25] Herrington, F.D., Carmody, R.J. and Goodyear, C.S. (2016) Modulation of NF-κB Signaling as a Therapeutic Target in Autoimmunity. SLAS Discovery, 21, 223-242. [Google Scholar] [CrossRef] [PubMed]
[26] 祁岗, 朱艳媚, 李焱, 等. NF-κB通路在自身免疫性甲状腺炎发病过程中的作用[J]. 实用医学杂志, 2018, 34(20): 3362-3366.
[27] 封潇添, 马剑雄, 王岩, 等. 青蒿素及其衍生物治疗骨科相关疾病的研究进展[J]. 中国中药杂志, 2024, 49(18): 4829-4840.
[28] Liu, H., Tian, Q., Ai, X., Qin, Y., Cui, Z., Li, M., et al. (2017) Dihydroartemisinin Attenuates Autoimmune Thyroiditis by Inhibiting the CXCR3/PI3K/AKT/NF-κB Signaling Pathway. Oncotarget, 8, 115028-115040. [Google Scholar] [CrossRef] [PubMed]
[29] 苗常鑫, 冷锦红. 薯蓣皂苷的药理作用及机制研究进展[J]. 中华中医药学刊, 2024, 42(11): 113-118.
[30] Zhang, C., Zhang, Q., Qin, L., Yan, Z., Wu, L. and Liu, T. (2023) Dioscin Ameliorates Experimental Autoimmune Thyroiditis via the mTOR and TLR4/NF-κB Signaling. Drug Design, Development and Therapy, 17, 2273-2285. [Google Scholar] [CrossRef] [PubMed]
[31] 郭风宜, 刘子玉, 王智民, 等. 益气化痰活血方对自身免疫性甲状腺炎小鼠肠道菌群的影响[J]. 时珍国医国药, 2023, 34(2): 292-295.
[32] Zhao, Z., Liu, Z., Song, N., et al. (2024) Based on SIRT1/NF-κB/NLRP3 Signal Pathway to Explore the Effect of Yiqi Huatan Huoxue Recipe on Inflammatory Injury in AIT Mice by Pyroptosis. Combinatorial Chemistry & High Throughput Screening.

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