围产期抑郁与焦虑共病的神经内分泌–免疫网络动态演变轨迹研究综述
A Review of the Dynamic Evolution Trajectory of Neuroendocrine-Immune Network in Comorbid Perinatal Depression and Anxiety
摘要: 围产期抑郁与焦虑的共病现象已成为孕产妇心理健康领域的重要问题，不仅对母婴安全构成严重威胁，还对家庭幸福产生深远影响。近年来的研究表明，神经内分泌系统与免疫系统之间的复杂互动在围产期精神障碍的发生和发展中起着关键作用。然而，这一交互作用的动态演变机制仍未得到充分阐明。本文系统性地综述了围产期抑郁与焦虑共病的神经内分泌–免疫网络的动态轨迹，重点分析了激素水平的波动、免疫功能的调节及神经炎症反应的时空特征及其相互影响。结合最新的分子生物学技术与临床研究成果，探讨了该网络的调控机制以及其潜在的生物标志物和治疗靶点。本文旨在为围产期精神障碍的早期诊断和精准治疗提供理论支持与研究方向，推动相关领域的深入发展。
Abstract: The co-occurrence of perinatal depression and anxiety has become an important issue in the field of maternal mental health. It not only poses a serious threat to the safety of mother and child but also has a profound impact on family happiness. Recent studies have shown that complex interactions between the neuroendocrine system and the immune system play a key role in the occurrence and development of perinatal mental disorders. However, the dynamic evolution mechanism of this interaction has not yet been fully elucidated. This article systematically reviews the dynamic trajectory of the neuroendocrine-immune network in comorbid perinatal depression and anxiety, focusing on the analysis of hormone level fluctuations, immune function regulation, and the spatiotemporal characteristics of neuroinflammatory responses and their mutual influences. Combining the latest molecular biology techniques and clinical research findings, it explores the regulatory mechanisms of this network and its potential biomarkers and therapeutic targets. The purpose of this article is to provide theoretical support and research directions for the early diagnosis and precise treatment of perinatal mental disorders, and to promote the in-depth development of related fields.
文章引用：朱梦妮, 李凌 (2025). 围产期抑郁与焦虑共病的神经内分泌–免疫网络动态演变轨迹研究综述. 心理学进展, 15(11), 327-335. https://doi.org/10.12677/ap.2025.1511608

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