烟酸缺乏症致慢性皮肤溃疡的多联技术治疗1例报告

A Case Report of Combined Modality Therapy for Chronic Skin Ulcer Caused by Nicotinic Acid Deficiency

摘要: 2023年7月，陇南市妇幼保健院创面修复科收治1例重型烟酸缺乏症所致皮肤溃疡患者，在给予高蛋白饮食、补充烟酸、抗炎、补液保持水电解质平衡、止痒、人血清白蛋白静滴等综合治疗的基础上，针对呈深II度烫伤样小腿溃疡创面，采用3%硼酸溶液冷敷(1周)、创面外涂湿润烧伤膏(2周)、继以外涂生肌膏(1周)的多技术联合治疗方案。经21天治疗，小腿溃疡基本愈合，患者出院；出院后随访1个月，创面完全愈合，无复发及瘢痕形成。本治疗方案为烟酸缺乏症所致难愈性皮肤溃疡的治疗提供了新思路，具有临床参考价值。

Abstract: In July 2023, a patient with severe nicotinic acid deficiency complicated by chronic skin ulcer was admitted to the Department of Wound Repair, Maternal and Child Health Hospital of Longnan City, Gansu Province. On the basis of systemic comprehensive treatment including high-protein diet, nicotinic acid supplementation, anti-inflammatory therapy, maintenance of fluid and electrolyte balance, antipruritics, and intravenous human albumin, a sequential topical treatment regimen was applied to the deep second-degree burn-like ulcer on the lower leg: cold compress with 3% boric acid solution (1 week), topical application of moist burn ointment (2 weeks), followed by topical application of muscle regeneration ointment (1 week). After 21 days of treatment, the ulcer was basically healed and the patient was discharged. Follow-up at one month after discharge showed complete wound healing without recurrence or scar formation. This regimen provides a new approach for the treatment of refractory skin ulcers caused by nicotinic acid deficiency and has clinical reference value.