5-ALA对线粒体的影响及其在神经退行性疾病中的应用前景
Mitochondrial Modulation by 5-Aminolevulinic Acid and Its Therapeutic Prospects in Neurodegenerative Disorders
DOI: 10.12677/acm.2025.15113308, PDF,    科研立项经费支持
作者: 黄旭涛*：南华大学衡阳医学院，湖南 衡阳；南华大学附属第七医院(湖南省荣军优抚医院)神经内科，湖南 长沙；王 芳#：南华大学衡阳医学院，湖南 衡阳
关键词: 5-氨基乙酰丙酸；线粒体；神经退行性疾病；帕金森病；血红素；5-Aminolevulinic Acid； Mitochondria； Neurodegenerative Diseases； Parkinson’s Disease； Heme
摘要: 5-氨基乙酰丙酸(5-aminolevulinic acid, 5-ALA)作为一种天然氨基酸衍生物，同时也是血红素合成的前体物质，已广泛应用于临床，尤其在光动力治疗(PDT)中显示出良好的前景。近年来，越来越多的研究表明，5-ALA不仅能促进线粒体功能的改善，还能通过调节细胞代谢、增强抗氧化能力、促进细胞自噬等机制，发挥其在神经退行性疾病中的潜在治疗效果。本文旨在综述5-ALA对线粒体功能的影响，总结其在临床的主要应用，探讨其在神经退行性疾病中的应用前景，并为相关疾病的治疗提供新的思路。
Abstract: 5-Aminolevulinic acid (5-ALA), a natural amino acid derivative and a precursor in heme biosynthesis, has been widely used in clinical practice, particularly showing promising results in photodynamic therapy (PDT). In recent years, increasing evidence suggests that 5-ALA not only promotes the improvement of mitochondrial function but also exerts potential therapeutic effects in neurodegenerative diseases through mechanisms such as regulating cellular metabolism, enhancing antioxidant capacity, and promoting autophagy. This article aims to review the impact of 5-ALA on mitochondrial function, summarize its main clinical applications, explore its potential in treating neurodegenerative diseases, and provide new insights for the treatment of related diseases.
文章引用：黄旭涛, 王芳. 5-ALA对线粒体的影响及其在神经退行性疾病中的应用前景[J]. 临床医学进展, 2025, 15(11): 1979-1986. https://doi.org/10.12677/acm.2025.15113308

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