心肾综合征的研究现状及进展
Research Status and Progress of Cardiorenal Syndrome
DOI: 10.12677/acm.2025.15113312, PDF,   
作者: 单泓达：承德医学院研究生学院，河北 承德；刘宇鹏*：秦皇岛市第一医院急诊科，河北 秦皇岛
关键词: 心肾综合征；病理生理学；生物标志物；Cardiorenal Syndrome； Pathophysiology； Biomarkers
摘要: 心肾综合征(Cardiorenal Syndrome, CRS)是指一组复杂的双向病理生理途径，涉及心脏和肾脏功能障碍。超过60%的ADHF住院患者患有慢性肾脏病(Chronic Kidney Disease)；而CKD的存在又会显著增加ADHF患者的死亡和心血管事件风险，二者相互影响，形成恶性循环。CRS病理生理机制复杂，涉及血流动力学、神经激素、炎症及氧化应激等多重途径。本文旨在系统回顾CRS的分类、病理机制、诊断生物标志物及治疗策略等方面的研究现状与最新进展，以期为临床实践和未来研究方向提供参考。
Abstract: Cardiorenal syndrome (CRS) represents a complex set of bidirectional pathophysiological pathways involving dysfunction of both the heart and kidneys. Chronic kidney disease (CKD) is present in over 60% of patients hospitalized for acute decompensated heart failure (ADHF). Conversely, the presence of CKD significantly increases the risk of mortality and cardiovascular events in ADHF patients, creating a vicious cycle where each condition exacerbates the other. The pathophysiology of CRS is multifaceted, involving hemodynamic derangements, neurohormonal activation, inflammation, and oxidative stress, among other pathways. This article aims to provide a systematic review of the current research and recent advances in the classification, pathological mechanisms, diagnostic biomarkers, and therapeutic strategies for CRS, with the goal of informing clinical practice and guiding future research directions.
文章引用：单泓达, 刘宇鹏. 心肾综合征的研究现状及进展[J]. 临床医学进展, 2025, 15(11): 2004-2009. https://doi.org/10.12677/acm.2025.15113312

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