pDoC的脑肠轴失衡：炎症因子谱特征与意识水平评估的关联
pDoC’s Brain-Gut Axis Imbalance: Association between Inflammatory Factor Profiles and Consciousness Level Assessment
摘要: 本文综述慢性意识障碍(Prolonged Disorders of Consciousness, pDoC)与脑肠轴失衡、炎症因子的关联机制及研究进展。脑肠轴失衡(菌群失调、肠屏障受损)引发全身炎症，破坏血脑屏障并诱发神经炎症，同时干扰神经递质与内分泌功能；IL-6、IL-1β等炎症因子直接损伤神经细胞、干扰递质代谢，其水平与意识障碍程度相关。文章旨在为pDoC的研究与治疗提供参考。
Abstract: This review summarizes the associative mechanisms and research progress between prolonged disorders of consciousness (pDoC), gut-brain axis imbalance, and inflammatory factors. Gut-brain axis imbalance, characterized by dysbiosis and impaired intestinal barrier function, triggers systemic inflammation, disrupts the blood-brain barrier, and induces neuroinflammation, while also interfering with neurotransmitter and endocrine functions. Inflammatory factors such as IL-6 and IL-1β directly damage neural cells, disturb neurotransmitter metabolism, and their levels correlate with the severity of consciousness disorders. This review aims to provide a comprehensive reference for the research and treatment of pDoC.
文章引用：李毅, 申峤, 白康康. pDoC的脑肠轴失衡：炎症因子谱特征与意识水平评估的关联[J]. 临床医学进展, 2025, 15(11): 2010-2015. https://doi.org/10.12677/acm.2025.15113313

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