嗜酸性粒细胞与AECOPD的相关性研究进展
Research Progress on the Correlation between Eosinophils and Acute Exacerbation of Chronic Obstructive Pulmonary Disease
摘要: 慢性阻塞性肺疾病急性加重期(AECOPD)是导致患者肺功能恶化、住院率及死亡率升高的关键阶段，疾病异质性显著，而嗜酸性粒细胞(EOS)作为重要的炎症标志物，在AECOPD的病情评估、治疗指导及预后预测中逐渐受到关注。本文系统梳理近年研究成果，从EOS在AECOPD中的炎症机制、临床特征关联、治疗指导价值及联合预测作用等方面展开综述，分析不同EOS临界值的临床意义及研究争议，旨在为AECOPD的精准诊疗提供参考，同时指出当前研究局限与未来探索方向。
Abstract: Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is a critical stage leading to the deterioration of patients’ lung function, as well as increased hospitalization and mortality rates, with significant disease heterogeneity. As an important inflammatory marker, eosinophils (EOS) have gradually attracted attention in the disease assessment, treatment guidance, and prognosis prediction of AECOPD. This article systematically reviews recent research findings, focusing on the inflammatory mechanisms of EOS in AECOPD, its association with clinical characteristics, its value in treatment guidance, and its combined predictive role. It also analyzes the clinical significance and research controversies of different EOS cutoff values, to provide references for the precise diagnosis and treatment of AECOPD, and highlights the limitations of current research and future directions.
文章引用：刘瑶, 白智远. 嗜酸性粒细胞与AECOPD的相关性研究进展[J]. 临床医学进展, 2025, 15(11): 2056-2067. https://doi.org/10.12677/acm.2025.15113319

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