结直肠癌患者术前血浆D-二聚体与临床病理特征之间的关系

The Relationship between Preoperative D-Dimer and Clinicopathological Characteristics in Patients with Colorectal Cancer

摘要: 目的：探究结直肠癌患者术前血浆D-二聚体水平与患者临床病理特征之间的关系。方法：收集115例我院于2022年1月至2024年12月经手术治疗的结直肠癌患者，根据D二聚体是否升高进行分组，结合患者临床病理特征，应用卡方检验分析患者D二聚体在不同临床病理特征之间是否存差异，应用Spearman相关分析探索D-二聚体水平与临床病理特征之间无相关性。结果：术后病理分期晚、存在淋巴结转移、脉管侵犯、肿瘤组织浸润肠壁深的患者往往存在D-二聚体异常升高，并且存在统计学差异(P < 0.05)，而D-二聚体水平在不同肿瘤分化程度、有无神经侵犯中无显著差异。此外，肿瘤指标CA199、CEA异常与血浆D-二聚体水平具有相关性。结论：术前血浆D-二聚体与结直肠癌患者的病情存在密切相关性，临床中可通过检测血浆D-二聚体水平来综合评估患者预后。

Abstract: Objective: To explore the relationship between the pre-operative plasma D-dimer levels and the clinicopathological characteristics of patients with colorectal cancer. Methods: A total of 115 patients with colorectal cancer who underwent surgical treatment in our hospital from January 2022 to December 2024 were collected. The patients were grouped according to whether the D-dimer level was elevated. Combined with the clinicopathological characteristics of the patients, the chi-square test was used to analyze whether there were differences in D-dimer levels among different clinicopathological characteristics, and Spearman’s correlation analysis was applied to explore the correlation between D-dimer and clinicopathological characteristics. Result: Patients with late pathological staging, lymph node metastasis, vascular invasion, and deep tumor tissue invasion of the intestinal wall often had elevated D-dimer levels, and there were statistical differences (P < 0.05). However, there were no significant differences in D-dimer levels among patients with different degrees of differentiation and with or without never invasion. In addition, abnormal tumor markers CA199 and CEA were correlated with plasma D-dimer. Conclusion: Pre-operative plasma D-dimer levels are closely related to the state of an illness in patients with colorectal cancer. In clinical practice, plasma D-dimer levels can be detected to comprehensively evaluate the prognosis of patients.