儿童孤独症谱系障碍共病情绪症状的临床特征及神经环路机制的研究进展
Emotional Comorbidity in Pediatric Autism Spectrum Disorder: A Review of Clinical Features and Neural Circuit Mechanisms
DOI: 10.12677/ijpn.2025.144011, PDF,    国家自然科学基金支持
作者: 刘彩燕, 张文彬：暨南大学附属第一医院精神医学科，广东 广州；师玲玲*：暨南大学附属第一医院精神医学科，广东 广州；暨南大学粤港澳中枢神经再生研究院，中枢神经再生教育部重点实验室，广州 广东
关键词: 孤独症谱系障碍；焦虑症状；抑郁症状；临床特征；神经环路；Autism Spectrum Disorder； Anxiety Symptoms； Depressive Symptoms； Clinical Characteristics； Neural Circuits
摘要: 孤独症谱系障碍是一种高共病率的神经发育障碍，以社交沟通障碍和重复刻板行为为核心症状。据统计，超过50%的ASD患者伴有焦虑、抑郁等情绪问题，导致临床表现复杂化、诊断困难及干预延迟，影响患者的社会功能与生活质量。目前，ASD共病情绪症状的机制尚未完全明确，治疗方案的疗效个体差异性大。因此，本文旨在梳理ASD共病焦虑与抑郁的临床表现特征，重点探讨其背后的神经环路机制，并综述现有及新兴的干预策略。旨在提倡早期甄别共病情绪障碍的ASD患者，并基于神经环路开发针对性的治疗策略，以期改善患者的整体生活质量。
Abstract: Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by a high rate of comorbidity, with core symptoms including deficits in social communication and the presence of restricted, repetitive patterns of behavior. According to statistics, over 50% of individuals with ASD experience emotional problems including anxiety and depression, which leads to increased complexity in clinical presentation, diagnostic challenges, and delays in intervention, ultimately affecting patients’ social functioning and quality of life. Currently, the underlying mechanisms of the comorbidity between ASD and emotional disorders remain incompletely understood, and treatment efficacy shows significant individual variability. Therefore, this review aims to systematically outline the clinical manifestations of ASD comorbid with anxiety and depression, with a focus on the underlying neural circuitry mechanisms, and to summarize existing and emerging intervention strategies. The goal is to advocate for the early identification of emotional comorbidities in ASD patients and to promote the development of targeted therapeutic strategies based on abnormalities in neural circuits, with the aim of improving their overall quality of life.
文章引用：刘彩燕, 张文彬, 师玲玲. 儿童孤独症谱系障碍共病情绪症状的临床特征及神经环路机制的研究进展[J]. 国际神经精神科学杂志, 2025, 14(4): 83-92. https://doi.org/10.12677/ijpn.2025.144011

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