早产儿血清总胆红素峰值与光疗持续时间的相关性分析

Correlation Analysis of Peak Serum Total Bilirubin in Premature Infants and Duration of Phototherapy

摘要: 目的：探讨早产儿血清总胆红素峰值与光疗持续时间之间的相关性，为临床制定个体化光疗方案提供依据。方法：采用回顾性队列研究方法，收集2022年1月至2025年6月我院新生儿重症监护室收治的70例接受光疗的早产儿临床资料。根据血清总胆红素峰值水平(临界值255 μmol/L)分为高胆红素组(n = 35)和低胆红素组(n = 35)。比较两组光疗持续时间、黄疸消退时间等指标，采用Pearson相关性分析探讨胆红素峰值与光疗持续时间的关系。结果：高胆红素组光疗持续时间显著长于低胆红素组(68.45 ± 12.36小时vs 45.72 ± 9.83小时，P < 0.01)。相关性分析显示，血清总胆红素峰值与光疗持续时间呈中等强度正相关(r = 0.62, P < 0.01)，决定系数R² = 0.38。两组光疗后胆红素下降值无显著差异(P > 0.05)，但高胆红素组黄疸消退时间更长(7.85 ± 1.45天vs 6.12 ± 1.23天，P < 0.01)。结论：早产儿血清总胆红素峰值与光疗持续时间存在显著正相关关系，是影响光疗时长的重要因素。临床应加强胆红素水平监测，结合个体情况制定光疗策略。

Abstract: Objective: To explore the correlation between the peak value of total bilirubin in the serum of premature infants and the duration of phototherapy, and to provide a basis for the formulation of individualized phototherapy regimens in clinical practice. Methods: A retrospective cohort study was conducted to collect the clinical data of 70 premature infants who received phototherapy and were admitted to the neonatal intensive care unit of our hospital from January 2022 to June 2025. According to the peak level of total serum bilirubin (critical value 255 μmol/L), the patients were divided into the high bilirubin group (n = 35) and the low bilirubin group (n = 35). The duration of phototherapy, the time for jaundice to subside and other indicators were compared between the two groups. Pearson correlation analysis was used to explore the relationship between the peak bilirubin and the duration of phototherapy. Result: The duration of phototherapy in the high bilirubin group was significantly longer than that in the low bilirubin group (68.45 ± 12.36 hours vs 45.72 ± 9.83 hours, P < 0.01). Correlation analysis showed that the peak value of total serum bilirubin was moderately positively correlated with the duration of phototherapy (r = 0.62, P < 0.01), with a coefficient of determination R² = 0.38. There was no significant difference in the decrease of bilirubin between the two groups after phototherapy (P > 0.05), but the jaundice regression time was longer in the high bilirubin group (7.85 ± 1.45 days vs 6.12 ± 1.23 days, P < 0.01). Conclusion: There is a significant positive correlation between the peak value of total bilirubin in the serum of premature infants and the duration of phototherapy, which is an important factor affecting the duration of phototherapy. Clinically, the monitoring of bilirubin levels should be strengthened, and phototherapy strategies should be formulated in combination with individual conditions.