中医药防治PCOS-IR的研究进展

Research Progress on the Prevention and Treatment of PCOS-IR with Traditional Chinese Medicine

摘要: 多囊卵巢综合征(polycystic ovary syndrome, PCOS)是育龄期女性常见的生殖内分泌及代谢紊乱性疾病，以稀发排卵或无排卵﹑雄激素过多和胰岛素抵抗为主要特征，临床表现主要有月经稀发或闭经、不孕﹑肥胖、多毛﹑痤疮等，并常伴有高雄激素血症、高胰岛素血症(HI)和胰岛素抵抗(IR)等表现，是妇科常见的疑难病症。胰岛素抵抗(insulin resistance, IR)属于PCOS的重要病理改变之一，是连接生殖障碍与代谢障碍的桥梁。因此，提高胰岛素敏感性，改善IR对于治疗PCOS具有重要的意义。文章检索近十年的文献，围绕胰岛素抵抗的中医病因病机、中医药治疗等方面进行综述，以期为PCOS-IR的认识和防治提供借鉴。

Abstract: Polycystic ovary syndrome (PCOS) is a common reproductive endocrine and metabolic disorder among women of reproductive age, characterized by oligo-ovulation or anovulation, hyperandrogenism, and insulin resistance. Its clinical manifestations primarily include oligomenorrhea or amenorrhea, infertility, obesity, hirsutism, and acne. It is often accompanied by hyperandrogenemia, hyperinsulinemia (HI), and insulin resistance (IR), making it a common and challenging gynecological condition. Insulin resistance (IR) is one of the key pathological changes in PCOS and serves as a bridge connecting reproductive disorders with metabolic dysfunctions. Therefore, enhancing insulin sensitivity and improving IR are of significant importance in the treatment of PCOS. This article reviews literature from the past decade, focusing on the etiology and pathogenesis of insulin resistance in Traditional Chinese Medicine (TCM) and its treatment with TCM, aiming to provide insights for the understanding, prevention, and treatment of PCOS-IR.