饮食限制对秀丽隐杆线虫的代谢重编程影响机制研究进展

Review on Research Progress of Metabolic Reprogramming Mechanisms in Caenorhabditis elegans Induced by Dietary Restriction

摘要: 新时代，随着人们饮食的变化，许多健康问题出现，为何需要进行适当的进食把控成为热点。秀丽隐杆线虫具有生长周期短，遗传背景清晰，与人类一部分基因同源等优点，目前被广泛运用，在探究人类健康代谢的问题上，更是用于宣传健康饮食重要性的良好的模式生物。文章综述了饮食限制如何影响线虫的能量代谢途径、调控信号通路，最终导致细胞层面发生适应性变化等方面。在饮食限制下，对线虫的代谢重编程进行系统分析，总结当前的研究现状、存在的争议和未来的研究方向，旨在进一步深入探究，饮食限制与代谢重编程之间的关系，提供较为全面的参考，同时也希望为其他生物领域的相关研究提供一定的借鉴。

Abstract: In the new era, with the change of people’s diet, many health problems appear, so why it is necessary to control eating properly has become a hot spot. Caenorhabditis elegans has the advantages of short growth cycle, clear genetic background and homology with some human genes. At present, it is widely used, and it is also used to publicize the importance of healthy diet and a good model organism in exploring the healthy metabolism of human beings. In this paper, how dietary restriction affects the energy metabolism pathway, regulation signal pathway of nematodes, and finally leads to adaptive changes at the cellular level. Under dietary restriction, the metabolic reprogramming of nematodes was systematically analyzed, and the current research status, existing disputes and future research direction were summarized, aiming at further exploring the relationship between dietary restriction and metabolic reprogramming, providing a more comprehensive reference, and also hoping to provide some reference for related research in other biological fields.